Repositório Digital

A- A A+

CYP1A1, CYP2E1, GSTM1, GSTT1, GSTP1, and TP53 polymorphisms : do they indicate susceptibility to chronic obstructive pulmonary disease and non-small-cell lung cancer?

.

CYP1A1, CYP2E1, GSTM1, GSTT1, GSTP1, and TP53 polymorphisms : do they indicate susceptibility to chronic obstructive pulmonary disease and non-small-cell lung cancer?

Mostrar registro completo

Estatísticas

Título CYP1A1, CYP2E1, GSTM1, GSTT1, GSTP1, and TP53 polymorphisms : do they indicate susceptibility to chronic obstructive pulmonary disease and non-small-cell lung cancer?
Autor Gaspar, Pedro de Abreu
Moreira, José da Silva
Kvitko, Katia
Torres, Martiela Ribeiro
Moreira, Ana
Weimer, Tania de Azevedo
Abstract Gene polymorphisms of phase I (CYP1A1 and CYP2E of cytochrome P,) and phase II (GSTM1, GSTT1 and GSTP1 of glutathione-S-transferase,) enzymes and the TP53 tumor suppressor gene were studied as markers in a sample of 262 Brazilians of European descent, the sample consisting of 97 patients with non-small-cell lung cancer (NSCLC), 75 patients with chronic obstructive pulmonary disease (COPD) and 90 control individuals. For NSCLC, we found no significant relationship between any of the markers studied and susceptibility to this disease. With respect to COPD, although the distribution of the CYP1A1, GSTM1, GSTP1, GSTT1 and TP53 genotypes was similar to that of the controls the frequency of the CYP2E1*1A/*5B heterozygote was about 6 times higher in COPD patients than in controls (OR= 6.3; CI = 1.1-35.5 for p = 0.04) Individuals who presented the GSTT1 null phenotype andGSTP1 Ile/Val genotype had a risk about four times higher (OR= 4.0; CI = 1.2–14.6 for p = 0.02) of having COPD than individuals without these genotypes, the same being true for individuals having the GSTT1 null phenotype and CYP1A1*1A/*2A genotype (OR= 3.7; 1.1–14.6 for p = 0.04).These results suggest that the CYP2E1 and GSTT1 + GSTP or GSTT1 + CYP1A1 polymorphisms may be predictive of susceptibility to COPD, at least in this population of European ancestry.
Contido em Genetics and molecular biology. Vol. 27, no. 2 (June 2004), p. 133-138
Assunto Doença pulmonar obstrutiva crônica
Genética
Neoplasias
Polimorfismo
[en] Chronic obstructive pulmonary disease
[en] CYPs
[en] Genetic susceptibility
[en] GSTs and TP53 polymorphisms
[en] on-small-cell lung cancer
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/23376
Arquivos Descrição Formato
000474645.pdf (251.1Kb) Texto completo (inglês) Adobe PDF Visualizar/abrir

Este item está licenciado na Creative Commons License

Este item aparece na(s) seguinte(s) coleção(ões)


Mostrar registro completo

Percorrer



  • O autor é titular dos direitos autorais dos documentos disponíveis neste repositório e é vedada, nos termos da lei, a comercialização de qualquer espécie sem sua autorização prévia.
    Projeto gráfico elaborado pelo Caixola - Clube de Criação Fabico/UFRGS Powered by DSpace software, Version 1.8.1.