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Matrix metalloproteinase gene polymorphisms in patients with coronary artery disease

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Matrix metalloproteinase gene polymorphisms in patients with coronary artery disease

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Título Matrix metalloproteinase gene polymorphisms in patients with coronary artery disease
Autor Dalepiane, Vanessa L. N.
Ferreira, Daiane Nicoli Silvello dos Santos
Paludo, Crislaine A.
Roisenberg, Israel
Simon, Daniel
Abstract Matrix metalloproteinases (MMPs) play an important role in the pathogenesis of atherosclerosis, the pathology underlying the majority of coronary artery disease (CAD). In this study we tested the hypothesis that polymorphic variation in the MMP genes influences the risk of developing atherosclerosis. We analyzed functional polymorphisms in the promoter of the MMP-1, MMP-3, MMP-9 and MMP-12 genes in 183 Brazilian Caucasian individuals submitted to coronary angiography, of which 67 (37%) had normal coronary arteries (control group) and 116 (63%) had CAD (CAD patient group). The -1607 1G/2G MMP-1, -1171 5A/6A MMP-3, -1562 C/T MMP-9, -82 A/G MMP-12 polymorphisms were analyzed by PCR followed by restriction digestion. No significant differences were observed in allele frequencies between the CAD patients and controls. Haplotype analysis showed no differences between the CAD patients and controls. There was a significant difference in the severity of CAD, as assessed by the number of diseased vessels, in MMP-1 1G/1G homozygous individuals and in those homozygous for the 6A allele of the MMP-3 polymorphism. However, multivariate analysis showed that diabetes mellitus was the only variable independently associated with CAD severity. Our findings indicated that MMP polymorphisms have no significant impact on the risk and severity of CAD.
Contido em Genetics and molecular biology. Ribeirão Preto. Vol. 30, no. 3 (Sept. 2007), p.505-510
Assunto Arteriosclerose coronária
Genética
Polimorfismo
[en] Atherosclerosis
[en] Coronary artery disease
[en] Gene polymorphisms
[en] Matrix metalloproteinases
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/23401
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