Repositório Digital

A- A A+

Prevalence of the serpin peptidase inhibitor (alpha-1-antitrypsin) PI*S and PI*Z alleles in Brazilian children with liver disease

.

Prevalence of the serpin peptidase inhibitor (alpha-1-antitrypsin) PI*S and PI*Z alleles in Brazilian children with liver disease

Mostrar registro completo

Estatísticas

Título Prevalence of the serpin peptidase inhibitor (alpha-1-antitrypsin) PI*S and PI*Z alleles in Brazilian children with liver disease
Autor Baldo, Guilherme
Ayala, Ana
Melendez, Matias Eliseo
Nonnemacher, Karina
Lima, Luciane Cauduro
Leistner-Segal, Sandra
Kieling, Carlos Oscar
Vieira, Sandra Maria Gonçalves
Ferreira, Cristina Helena Targa
Silveira, Themis Reverbel da
Giugliani, Roberto
Matte, Ursula da Silveira
Abstract Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1) deficiency is one of the main genetic causes related to liver disease in children. In SERPINA1 deficiency the most frequent SERPINA1 alleles found are the PI*S and PI*Z alleles. We used the polymerase chain reaction and the amplification created restriction site (ACRS) technique to investigate the prevalence of the PI*S and PI*Z alleles in a group of Brazilian children (n = 200) with liver disease and established the general frequency of the PI*S allele in our population. We found a significant association of the PI*Z allele and liver disease, but no such relationship was found for the PI*S allele. Our results show that SERPINA1 deficiency due to the PI*Z allele, even when heterozygous, is a frequent cause of liver disease in our group of Brazilian children but that the PI*S allele does not confer an increased risk of hepatic disorders in our group of Brazilian children
Contido em Genetics and molecular biology. Ribeirão Preto. Vol. 31, n. 2 (Jun. 2008), p. 423-426
Assunto Glycine max
Plantas transgênicas
Soja : Controle biologico : Lagarta
[en] Alpha-1-antitrypsin deficiency
[en] Liver disease
[en] Pediatric patients
[en] SERPINA1
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/23408
Arquivos Descrição Formato
000667260.pdf (77.95Kb) Texto completo (inglês) Adobe PDF Visualizar/abrir

Este item está licenciado na Creative Commons License

Este item aparece na(s) seguinte(s) coleção(ões)


Mostrar registro completo

Percorrer



  • O autor é titular dos direitos autorais dos documentos disponíveis neste repositório e é vedada, nos termos da lei, a comercialização de qualquer espécie sem sua autorização prévia.
    Projeto gráfico elaborado pelo Caixola - Clube de Criação Fabico/UFRGS Powered by DSpace software, Version 1.8.1.