Repositório Digital

A- A A+

Analysis of mRNA transcripts in chronic myeloid leukemia patients

.

Analysis of mRNA transcripts in chronic myeloid leukemia patients

Mostrar registro completo

Estatísticas

Título Analysis of mRNA transcripts in chronic myeloid leukemia patients
Autor Meissner, Rosely de Vasconcellos
Covas, Dimas T.
Dias, Paula Menna Barreto
Job, Fani Martins
Leite, Marcia
Nardi, Nance Beyer
Abstract The nature of BCR/ABL hybrid mRNA was analyzed by RT-PCR in cells from 33 patients (22 males, 11 females) with chronic myeloid leukemia (CML). b3a2 mRNA was found in 14 cases, whereas 13 patients had b2a2 mRNA and six had both kinds of mRNA, with a predominance of the b3a2 type. The type of mRNA present showed no significant correlation with age, hemoglobin level, number of leukocytes and platelets, percentage of blasts or basophils or the presence of splenomegaly at diagnosis. There was also no correlation with sex or duration of the chronic phase. When these results were combined with those reported by other groups, a significant association (P = 0.029) was observed for mRNA type vs. sex, with a predominance of men in the groups expressing b2a2 (2.68:1) and b3a2 (1.33:1). We conclude that the classification of patients according to mRNA type does not homogenize the clinical and hematological data within groups, where variance is large, nor does it allow a differentiation between groups.
Contido em Genetics and molecular biology. Ribeirão Preto. Vol. 22, no. 4 (1999), p. 475-479.
Assunto Genética
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/23491
Arquivos Descrição Formato
000293487.pdf (30.28Kb) Texto completo (inglês) Adobe PDF Visualizar/abrir

Este item está licenciado na Creative Commons License

Este item aparece na(s) seguinte(s) coleção(ões)


Mostrar registro completo

Percorrer



  • O autor é titular dos direitos autorais dos documentos disponíveis neste repositório e é vedada, nos termos da lei, a comercialização de qualquer espécie sem sua autorização prévia.
    Projeto gráfico elaborado pelo Caixola - Clube de Criação Fabico/UFRGS Powered by DSpace software, Version 1.8.1.