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dc.contributor.authorBuitelaar, Jan K.pt_BR
dc.contributor.authorCaye, Arthurpt_BR
dc.contributor.authorLeffa, Douglas Teixeirapt_BR
dc.contributor.authorRohde, Luis Augusto Paimpt_BR
dc.contributor.authorBanaschewski, Tobiaspt_BR
dc.date.accessioned2023-08-01T03:33:20Zpt_BR
dc.date.issued2018pt_BR
dc.identifier.issn1662-5153pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/262903pt_BR
dc.description.abstractAttention-Deficit Hyperactivity Disorder (ADHD) is a complex and heterogeneous neurodevelopmental condition for which curative treatments are lacking. Whilst pharmacological treatments are generally effective and safe, there is considerable inter-individual variability among patients regarding treatment response, required dose, and tolerability. Many of the non-pharmacological treatments, which are preferred to drug-treatment by some patients, either lack efficacy for core symptoms or are associated with small effect sizes. No evidence-based decision tools are currently available to allocate pharmacological or psychosocial treatments based on the patient's clinical, environmental, cognitive, genetic, or biological characteristics. We systematically reviewed potential biomarkers that may help in diagnosing ADHD and/or stratifying ADHD into more homogeneous subgroups and/or predict clinical course, treatment response, and long-term outcome across the lifespan. Most work involved exploratory studies with cognitive, actigraphic and EEG diagnostic markers to predict ADHD, along with relatively few studies exploring markers to subtype ADHD and predict response to treatment. There is a critical need for multisite prospective carefully designed experimentally controlled or observational studies to identify biomarkers that index inter-individual variability and/or predict treatment response.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofFrontiers in behavioral neuroscience. Lausanne. Vol. 16 (2022), artigo 900981, p. 1-25pt_BR
dc.rightsOpen Accessen
dc.subjectAttention-deficit hyperactivity disorderen
dc.subjectBiomarcadorespt_BR
dc.subjectTranstorno do déficit de atenção com hiperatividadept_BR
dc.subjectADHDen
dc.subjectPrecision medicineen
dc.subjectMedicina de precisãopt_BR
dc.subjectBiomarkeren
dc.subjectRevisão sistemáticapt_BR
dc.subjectHeterogeneityen
dc.subjectInterindividual variabilityen
dc.titleToward precision medicine in ADHDpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001171858pt_BR
dc.type.originEstrangeiropt_BR


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