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Pharmacological action of tick saliva upon haemostasis and the neutralization ability of sera from repeatedly infested hosts

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Pharmacological action of tick saliva upon haemostasis and the neutralization ability of sera from repeatedly infested hosts

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Título Pharmacological action of tick saliva upon haemostasis and the neutralization ability of sera from repeatedly infested hosts
Autor Reck Junior, José
Oliveira, Markus Berger
Marks, Fernanda Simone
Zingali, Russolina Benedeta
Canal, Cláudio Wageck
Ferreira, Carlos Alexandre Sanchez
Guimaraes, Jorge Almeida
Termignoni, Carlos
Abstract Ticks are blood-feeding arthropods widely distributed in the world and vectors of several diseases. As haematophagy demands evasion strategies and repeatedly infested hosts develop protective immune responses, we investigated the mechanisms of the Rhipicephalus (Boophilus) microplus saliva anti-haemostatic activity and the possible relationship between the acquired natural anti-tick host resistance and anti-haemostatic action. For this purpose, we studied the effects of R. microplus saliva on different pathways of haemostasis and tested whether repeated infested bovine sera (RIBS) are able to abolish salivary anti-haemostatic activities. R. microplus saliva (i) displays inhibitory activity upon collagen-induced platelet aggregation; (ii) inhibits the induction of endothelial pro-coagulant state ; and (iii) reduces thrombogenesis in vivo. RIBS were shown to be able to partially block the delay of coagulation and the anti-thrombotic effect of saliva, and to totally abolish the modulation of endothelium activation. Conversely, RIBS has no effect on the inhibition of platelet aggregation. These results show, for the first time, the neutralization ability of sera from acquired resistance hosts against tick antihaemostatics. Moreover, this is the first report of a haematophagous parasite able to modulate endothelial cell procoagulant state, and addresses the presence of anti-platelet and anti-thrombotic activity in R. microplus saliva.
Contido em Parasitology. Cambridge, United Kingdom. Vol. 136, no. 11 (Sept. 2009), p. 1339-1349
Assunto Bioquímica
Boophilus microplus
Carrapatos
Coagulação sanguínea
Hemostasia
[en] Bovine resistance
[en] Coagulation
[en] Endothelium
[en] Haematophagous
[en] Haemostasis
[en] Platelet
[en] Rhipicephalus (Boophilus) microplus
[en] Thrombosis
[en] Tick
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/27465
Arquivos Descrição Formato
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