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Green propolis phenolic compounds act as vaccine adjuvants, improving humoral and cellular responses in mice inoculated with inactivated vaccines

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Green propolis phenolic compounds act as vaccine adjuvants, improving humoral and cellular responses in mice inoculated with inactivated vaccines

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Título Green propolis phenolic compounds act as vaccine adjuvants, improving humoral and cellular responses in mice inoculated with inactivated vaccines
Autor Fischer, Geferson
Paulino, Niraldo
Ribeiro, Maria Cristina Marcucci
Siedler, Bianca Sica
Munhoz, Lívia Silveira
Finger, Paula Fonseca
Vargas, Gilberto D`Avila
Hübner, Sílvia de Oliveira
Vidor, Telmo
Roehe, Paulo Michel
Abstract Adjuvants play an important role in vaccine formulations by increasing their immunogenicity. In this study, the phenolic compound-rich J fraction (JFR) of a Brazilian green propolis methanolic extract stimulated cellular and humoral immune responses when co-administered with an inactivated vaccine against swine herpesvirus type 1 (SuHV-1). When compared to control vaccines that used aluminium hydroxide as an adjuvant, the use of 10 mg/dose of JFR significantly increased (p < 0.05) neutralizing antibody titres against SuHV-1, as well as the percentage of protected animals following SuHV-1 challenge (p < 0.01). Furthermore, addition of phenolic compounds potentiated the performance of the control vaccine, leading to increased cellular and humoral immune responses and enhanced protection of animals after SuHV-1 challenge (p < 0.05). Prenylated compounds such as Artepillin C that are found in large quantities in JFR are likely to be the substances that are responsible for the adjuvant activity.
Contido em Memórias do Instituto Oswaldo Cruz : an international journal of biological and biomedical research. Vol. 105, no. 7 (nov. 2010), p. 908-913
Assunto Compostos fenólicos
Imunidade celular
Imunidade humoral
Propolis
Vacinas
[en] Cellular immunity
[en] Humoral immunity
[en] Phenolic compounds
[en] Propolis
[en] Vaccines
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/28852
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