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dc.contributor.authorFischer, Gefersonpt_BR
dc.contributor.authorPaulino, Niraldopt_BR
dc.contributor.authorRibeiro, Maria Cristina Marcuccipt_BR
dc.contributor.authorSiedler, Bianca Sicapt_BR
dc.contributor.authorMunhoz, Lívia Silveirapt_BR
dc.contributor.authorFinger, Paula Fonsecapt_BR
dc.contributor.authorVargas, Gilberto D`Avilapt_BR
dc.contributor.authorHübner, Sílvia de Oliveirapt_BR
dc.contributor.authorVidor, Telmopt_BR
dc.contributor.authorRoehe, Paulo Michelpt_BR
dc.date.accessioned2011-05-04T06:00:15Zpt_BR
dc.date.issued2009pt_BR
dc.identifier.issn0074-0276pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/28852pt_BR
dc.description.abstractAdjuvants play an important role in vaccine formulations by increasing their immunogenicity. In this study, the phenolic compound-rich J fraction (JFR) of a Brazilian green propolis methanolic extract stimulated cellular and humoral immune responses when co-administered with an inactivated vaccine against swine herpesvirus type 1 (SuHV-1). When compared to control vaccines that used aluminium hydroxide as an adjuvant, the use of 10 mg/dose of JFR significantly increased (p < 0.05) neutralizing antibody titres against SuHV-1, as well as the percentage of protected animals following SuHV-1 challenge (p < 0.01). Furthermore, addition of phenolic compounds potentiated the performance of the control vaccine, leading to increased cellular and humoral immune responses and enhanced protection of animals after SuHV-1 challenge (p < 0.05). Prenylated compounds such as Artepillin C that are found in large quantities in JFR are likely to be the substances that are responsible for the adjuvant activity.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofMemórias do Instituto Oswaldo Cruz : an international journal of biological and biomedical research. Vol. 105, no. 7 (nov. 2010), p. 908-913pt_BR
dc.rightsOpen Accessen
dc.subjectPropolisen
dc.subjectPropolispt_BR
dc.subjectCompostos fenólicospt_BR
dc.subjectPhenolic compoundsen
dc.subjectVaccinesen
dc.subjectVacinaspt_BR
dc.subjectImunidade celularpt_BR
dc.subjectHumoral immunityen
dc.subjectImunidade humoralpt_BR
dc.subjectCellular immunityen
dc.titleGreen propolis phenolic compounds act as vaccine adjuvants, improving humoral and cellular responses in mice inoculated with inactivated vaccinespt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000765451pt_BR
dc.type.originNacionalpt_BR


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