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Occupational therapy in spinocerebellar ataxia type 3: an open-label trial

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Occupational therapy in spinocerebellar ataxia type 3: an open-label trial

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Título Occupational therapy in spinocerebellar ataxia type 3: an open-label trial
Autor Silva, Renata Cristina Rocha da
Saute, Jonas Alex Morales
Silva, Andrew Chaves Feitosa da
Coutinho, Ana Carolina de Oliveira
Pereira, Maria Luiza Saraiva
Jardim, Laura Bannach
Abstract Occupational therapy (OT) is a profession concerned with promoting health and well-being through occupation, by enabling handicapped people to participate in the activities of everyday life. OT is part of the clinical rehabilitation of progressive genetic neurodegenerative diseases such as spinocerebellar ataxias; however, its effects have never been determined in these diseases. Our aim was to investigate the effect of OT on both physical disabilities and depressive symptoms of spinocerebellar ataxia type 3 (SCA3) patients. Genomically diagnosed SCA3 patients older than 18 years were invited to participate in the study. Disability, as evaluated by functional independence measurement and Barthel incapacitation score, Hamilton Rating Scale for Depression, and World Health Organization Quality of Life questionnaire (WHOQOL-BREF), was determined at baseline and after 3 and 6 months of treatment. Twenty-six patients agreed to participate in the study. All were treated because OT prevents blinding of a control group. Fifteen sessions of rehabilitative OT were applied over a period of 6 months. Difficult access to food, clothing, personal hygiene, and leisure were some of the main disabilities focused by these patients. After this treatment, disability scores and quality of life were stable, and the Hamilton scores for depression improved. Since no medication was started up to 6 months before or during OT, this improvement was related to our intervention. No association was found between these endpoints and a CAG tract of the MJD1 gene (CAGn), age, age of onset, or neurological scores at baseline (Spearman test). Although the possibly temporary stabilization of the downhill disabilities as an effect of OT remains to be established, its clear effect on depressive symptoms confirms the recommendation of OT to any patient with SCA3 or spinocerebellar ataxia.
Contido em Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Vol. 43, n. 6 (jun. 2010), p. 537-542
Assunto Doença de Machado-Joseph
Ensaios clínicos como assunto
Terapia ocupacional
[en] Depression
[en] Machado-Joseph disease
[en] Occupational therapy
[en] Polyglutamine diseases
[en] Rehabilitation
[en] Spinocerebellar ataxia 3
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/29629
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