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Characterization of bone repair in rat femur after treatment with calcium phosphate cement and autogenous bone graft

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Characterization of bone repair in rat femur after treatment with calcium phosphate cement and autogenous bone graft

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Título Characterization of bone repair in rat femur after treatment with calcium phosphate cement and autogenous bone graft
Autor Puricelli, Edela
Corsetti, Adriana
Ponzoni, Deise
Martins, Gustavo Lisboa
Leite, Mauro Gomes Trein
Santos, Luis Alberto dos
Abstract Background: In this study, the biocompatibility, stability and osteotransductivity of a new cement based on alphatricalcium phosphate (alpha-TCP) were investigated in a bone repair model using a rat model. Methods: The potential of alpha-TCP on bone repair was compared to autogenous bone grafting, and unfilled cavities were used as negative control. Surgical cavities were prepared and designated as test (T), implanted with alpha-TCP blocks; negative control (C - ), unfilled; and positive control (C + ), implanted with autogenous bone graft. Results were analyzed on postoperative days three, seven, 14, 21 and 60. Results: The histological analyses showed the following results. Postoperative day three: presence of inflammatory infiltrate, erythrocytes and proliferating fibroblasts in T, C - and C + samples. Day seven: extensive bone neoformation in groups T and C + , and beginning of alpha-TCP resorption by phagocytic cells. Days 14 and 21: osteoblastic activity in the three types of cavities. Day 60: In all samples, neoformed bone similar to surrounding bone. Moderate interruption on the ostectomized cortical bone. Conclusions: Bone neoformation is seen seven days after implantation of alpha-TCP and autogenous bone. Comparison of C - with T and C + samples showed that repair is faster in implanted cavities; on day 60, control groups presented almost complete bone repair. Alpha-TCP cement presents biocompatibility and osteotransductivity, besides stability, but 60 days after surgery the cavities were not closed.
Contido em Head & Face Medicine [recurso eletrônico]. London. Vol. 6, (28 June 2010), 8 p.
Assunto Cimentos
Enxerto osseo
Materiais biocompativeis
Regeneração óssea
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/30488
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