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High vancomycin resistance among biofilms produced by staphylococcus species isolated from central venous catheters

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High vancomycin resistance among biofilms produced by staphylococcus species isolated from central venous catheters

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Título High vancomycin resistance among biofilms produced by staphylococcus species isolated from central venous catheters
Autor Antunes, Ana Lucia Souza
Bonfanti, Jéssica Weis
Perez, Leandro Reus Rodrigues
Pinto, Camille Catani Ferreira
Freitas, Ana Lucia Peixoto de
Macedo, Alexandre José
Barth, Afonso Luis
Abstract Biofilm production is an important mechanism that allows microbes to escape host defences and antimicrobial therapy. Vancomycin has been used largely for the treatment of methicillin-resistant staphylococcal infections. Here, we determined the minimal inhibitory concentration (MIC) and minimal biofilm eradication concentration (MBEC) for 82 Staphylococcus species isolated from central venous catheters (CVC). Our results showed that the 41 strong and moderate-biofilm-producing isolates presented a higher MBEC/MIC ratio for vancomycin than the 24 weak-biofilm-producing isolates, illustrating the importance of biofilm production ability and the difficulty in treating biofilm-related infections. The MBEC was significantly higher in moderate-biofilm-producing isolates than in weak-biofilm-producing isolates (p < 0.001) and in strong-biofilm-producing isolates than in weak-biofilm-producing isolates (p = 0.001). The correlation between the MIC and the MBEC was poor. Based on our results, we recommend that bacterial biofilms be suspected in all cases of CVC infection.
Contido em Memórias do Instituto Oswaldo Cruz : an international journal of biological and biomedical research. Rio de Janeiro. Vol. 106, n. 1 (Feb. 2011), p. 51-55
Assunto Biofilmes
Cateterismo venoso central
Infecções bacterianas
Resistência à vancomicina
Staphylococcus aureus
[en] Biofilm
[en] Staphylococcus spp
[en] Vancomycin
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/30542
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