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dc.contributor.authorLecke, Sheila Büneckerpt_BR
dc.contributor.authorMorsch, Debora Martinhopt_BR
dc.contributor.authorSpritzer, Poli Marapt_BR
dc.date.accessioned2011-11-11T01:19:10Zpt_BR
dc.date.issued2011pt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/34289pt_BR
dc.description.abstractAdipose tissue secretes a variety of adipokines, including leptin and adiponectin, which are involved in endocrine processes regulating glucose and fatty metabolism, energy expenditure, inflammatory response, immunity, cardiovascular function, and reproduction. The present article describes the fluctuations in circulating leptin and adiponectin as well as their patterns of secretion in women from birth to menopause. During pregnancy, leptin and adiponectin seem to act in an autocrine/paracrine fashion in the placenta and adipose tissue, playing a role in the maternal-fetal interface and contributing to glucose metabolism and fetal development. In newborns, adiponectin levels are two to three times higher than in adults. Full-term newborns have significantly higher leptin and adiponectin levels than preterms, whereas small-for-gestational-age infants have lower levels of these adipokines than adequate-for-gestational-age newborns. However, with weight gain, leptin concentrations increase significantly. Children between 5 and 8 years of age experience an increase in leptin and a decrease in adiponectin regardless of body mass index, with a reversal of the newborn pattern for adiponectin: plasma adiponectin levels at age five are inversely correlated with percentage of body fat. In puberty, leptin plays a role in the regulation of menstrual cycles. In adults, it has been suggested that obese individuals exhibit both leptin resistance and decreased serum adiponectin levels. In conclusion, a progressive increase in adiposity throughout life seems to influence the relationship between leptin and adiponectin in women.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 44, no. 5 (May 2011), p. 381-387pt_BR
dc.rightsOpen Accessen
dc.subjectFemininopt_BR
dc.subjectFemaleen
dc.subjectAdiposityen
dc.subjectAdiposidadept_BR
dc.subjectLeptinapt_BR
dc.subjectLeptinen
dc.subjectAdiponectinen
dc.subjectAdiponectinapt_BR
dc.titleLeptin and adiponectin in the female life coursept_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000783541pt_BR
dc.type.originNacionalpt_BR


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