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Comparative histomorphometric analysis between α-Tcp cement and β-Tcp/Ha granules in the bone repair of rat calvaria

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Comparative histomorphometric analysis between α-Tcp cement and β-Tcp/Ha granules in the bone repair of rat calvaria

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Título Comparative histomorphometric analysis between α-Tcp cement and β-Tcp/Ha granules in the bone repair of rat calvaria
Autor Grandi, Gisela
Heitz, Claiton
Santos, Luis Alberto dos
Silva, Miguel Luciano
Sant'Ana Filho, Manoel
Pagnoncelli, Rogerio Miranda
Silva, Daniela Nascimento
Resumo This study compared the effect of two bioceramics on the process of bone repair: α-tricalcium phosphate (α-TCP) cement and β-tricalcium phosphate hydroxyapatite particles (β-TCP/HA). Calvarial defects were created in 50 rats, divided into two groups (α and β/HA). Software was used at 7, 21, 60, 90 and 120 days to assess bone formation. Mean new bone formation rates were as follows: α group, 1.6% at 7 days, 5.24% at 21 days, 24% at 60 days, 30.21% at 90 days and 50.59% at 120 days; β/HA group, 1.94% at 7 days, 2.53% at 21 days, 12.47% at 60 days, 26.84% at 90 days and 38.82% at 120 days; control group, 0.15% at 7 days, 10.12% at 21 days, 15.10% at 60 days, 18.94% at 90 days, 48.50% at 120 days. Both materials are osteoconductive and biocompatible. Perhaps the larger rate of new bone formation observed in the α-TCP group, it also occurs in the β-TCP/HA group within a longer time period.
Contido em Materials research : ibero-american journal of materials. São Carlos, SP. Vol. 14, no. 1 (Jan./Mar. 2011), p. 11-16
Assunto Materiais biocompativeis
[en] Bone defect
[en] Calcium phosphate
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/34353
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