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dc.contributor.authorLópez, R.V.M.pt_BR
dc.contributor.authorZago, Marco Antoniopt_BR
dc.contributor.authorEluf-Neto, Josept_BR
dc.contributor.authorCurado, Maria Paulapt_BR
dc.contributor.authorDaudt, Alexander Welaussenpt_BR
dc.contributor.authorSilva Junior, W.A. dapt_BR
dc.contributor.authorZanette, D.L.pt_BR
dc.contributor.authorLevi, J. E.pt_BR
dc.contributor.authorCarvalho, M.B. dept_BR
dc.contributor.authorKowalski, Luiz Paulopt_BR
dc.contributor.authorAbrahão, M.pt_BR
dc.contributor.authorGóis Filho, J.F. dept_BR
dc.contributor.authorBoffetta, Paolopt_BR
dc.contributor.authorWünsch Filho, Victorpt_BR
dc.date.accessioned2012-03-03T01:24:37Zpt_BR
dc.date.issued2011pt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/37319pt_BR
dc.description.abstractThe association of education, tobacco smoking, alcohol consumption, and interleukin-2 (IL-2 +114 and -384) and -6 (IL-6 -174) DNA polymorphisms with head and neck squamous cell carcinoma (HNSCC) was investigated in a cohort study of 445 subjects. IL-2 and IL-6 genotypes were determined by real-time PCR. Cox regression was used to estimate hazard ratios (HR) and 95% confidence intervals (95%CI) of disease-specific survival according to anatomical sites of the head and neck. Mean age was 56 years and most patients were males (87.6%). Subjects with 5 or more years of schooling had better survival in larynx cancer. Smoking had no effect on HNSCC survival, but alcohol consumption had a statistically significant effect on larynx cancer. IL-2 gene +114 G/T (HR = 0.52; 95%CI = 0.15-1.81) and T/T (HR = 0.22; 95%CI = 0.02-3.19) genotypes were associated with better survival in hypopharynx cancer. IL-2 +114 G/T was a predictor of poor survival in oral cavity/oropharynx cancer and larynx cancer (HR = 1.32; 95%CI = 0.61-2.85). IL-2 -384 G/T was associated with better survival in oral cavity/oropharynx cancer (HR = 0.80; 95%CI = 0.45-1.42) and hypopharynx cancer (HR = 0.68; 95%CI = 0.21-2.20), but an inverse relationship was observed for larynx cancer. IL-6 -174 G/C was associated with better survival in hypopharynx cancer (HR = 0.68; 95%CI = 0.26-1.78) and larynx cancer (HR = 0.93; 95%CI = 0.42-2.07), and C/C reduced mortality in larynx cancer. In general, our results are similar to previous reports on the value of education, smoking, alcohol consumption, and IL-2 and IL-6 genetic polymorphisms for the prognosis of HNSCC, but the risks due to these variables are small and estimates imprecise.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Vol. 44, n. 10 (out. 2011), p. 1006-1012pt_BR
dc.rightsOpen Accessen
dc.subjectSmokingen
dc.subjectNeoplasias de cabeça e pescoçopt_BR
dc.subjectTabacopt_BR
dc.subjectAlcoholen
dc.subjectInterleukinen
dc.subjectConsumo de bebidas alcoolicaspt_BR
dc.subjectEstudos de casospt_BR
dc.subjectHead and neck canceren
dc.subjectCancer prognosisen
dc.subjectSurvival analysisen
dc.titleEducation, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancerpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000795024pt_BR
dc.type.originNacionalpt_BR


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