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Associação dos níveis de BDNF (brain derived neurotrophic factor) no comprometimento cognitivo leve e na doença de Alzheimer

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Associação dos níveis de BDNF (brain derived neurotrophic factor) no comprometimento cognitivo leve e na doença de Alzheimer

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Título Associação dos níveis de BDNF (brain derived neurotrophic factor) no comprometimento cognitivo leve e na doença de Alzheimer
Autor Borba, Ericksen Mielle
Orientador Chaves, Marcia Lorena Fagundes
Data 2012
Nível Mestrado
Instituição Universidade Federal do Rio Grande do Sul. Faculdade de Medicina. Programa de Pós-Graduação em Medicina: Ciências Médicas.
Assunto Comprometimento cognitivo leve
Doença de Alzheimer
Fatores de crescimento neural
Fator neurotrófico derivado do encéfalo
Abstract Background: It has been suggested that there is an association between brain-derived neurotrophic factor (BDNF) and the neuropathology of Alzheimer’s disease (AD). However, little is known about the role of BDNF in subjects with mild cognitive impairment (MCI). In the present study, we investigated BDNF serum levels in healthy elderly, amnestic MCI, and mild to moderate AD patients in order to identify a possible role for this neurotrophin in preclinical and early stages of AD. Methods: BDNF serum levels were measured by sandwich-ELISA in healthy elderly (n=20), amnestic MCI patients (n=15) and AD patients (n=25), 12 mild and 13 moderate. MMSE scores, level of education and age were analyzed for a possible correlation with BDNF levels. Results: BDNF serum levels were significantly different between MCI patients and healthy subjects (p=0.003); MCI and mild AD patients (p=0.023); and MCI and moderate AD patients (p=0.050). BDNF showed no correlation with MMSE scores, age or level of education. Limitations: The small sample size in the present investigation could be a limitation. However, we carried out a power calculation that showed values higher than 80% for a confidence level of 95%. Conclusion: The fact that BDNF serum levels differentiated amnestic MCI patients from healthy elderly and AD patients suggests a possible role for BDNF as a preclinical biomarker of AD.
Tipo Dissertação
URI http://hdl.handle.net/10183/37451
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