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dc.contributor.authorDora, José Miguel Silvapt_BR
dc.contributor.authorGeib, Guilhermept_BR
dc.contributor.authorChakr, Rafael Mendonça da Silvapt_BR
dc.contributor.authorParis, Fernanda dept_BR
dc.contributor.authorMachado, Alice Beatriz Mombach Pinheiropt_BR
dc.contributor.authorLutz, Larissapt_BR
dc.contributor.authorSouza, Carolina Fischinger Moura dept_BR
dc.contributor.authorGoldani, Luciano Zubaranpt_BR
dc.date.accessioned2012-03-23T01:20:44Zpt_BR
dc.date.issued2008pt_BR
dc.identifier.issn1413-8670pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/37797pt_BR
dc.description.abstractMeningitis is a severe and potentially fatal form of tuberculosis. The diagnostic workup involves detection of acid-fast bacilli (AFB) in the cerebrospinal fluid (CSF) by microscopy or culture, however, the difficulty in detecting the organism poses a challenge to diagnosis. The use of the polymerase chain reaction (PCR) in the diagnostic approach to Mycobacterium tuberculosis (MTB) meningitis has been reported as a fast and accurate method, with several commercial kits available. As an alternative, some institutions have been developing inexpensive in house assays. In our institution, we use an in house PCR for tuberculosis. We analyzed the performance of our PCR for the diagnosis of MTB meningitis in 148 consecutive patients, using MTB culture as gold standard. The sensitivity and specificity of CSF PCR for the diagnosis of MTB meningitis was 50% and 98.6% respectively with a concordance with CSF mycobacterial culture of 96% (Kappa=0.52). In contrast to CSF cultures for MTB, our PCR test is a fast, simple and inexpensive tool to diagnose tuberculous meningitis with a performance similar to that obtained with the available commercial kits.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofThe Brazilian journal of infectious diseases. Vol. 12, no. 3 (Jun. 2008), p. 245-247pt_BR
dc.rightsOpen Accessen
dc.subjectTuberculose meníngeapt_BR
dc.subjectTuberculous meningitisen
dc.subjectDiagnosisen
dc.subjectReação em cadeia da polimerasept_BR
dc.subjectPolymerase chain reactionen
dc.subjectMycobacterium tuberculosispt_BR
dc.subjectPCRen
dc.subjectBrasilpt_BR
dc.subjectMycobacterium tuberculosisen
dc.titlePolymerase chain reaction as a useful and simple tool for rapid diagnosis of tuberculous meningitis in a brazilian tertiary care hospitalpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000719646pt_BR
dc.type.originEstrangeiropt_BR


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