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Bradykinin or acetylcholine as vasodilators to test endothelial venous function in healthy subjects

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Bradykinin or acetylcholine as vasodilators to test endothelial venous function in healthy subjects

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Título Bradykinin or acetylcholine as vasodilators to test endothelial venous function in healthy subjects
Autor Silva, Eneida Rejane Rabelo da
Rohde, Luis Eduardo Paim
Schaan, Beatriz D'Agord
Rubira, Marcelo Custódio
Ruschel, Karen Brasil
Plentz, Rodrigo D. M.
Consolim-Colombo, Fernanda Marciano
Irigoyen, Maria Claudia Costa
Moreno Junior, Heitor
Abstract INTRODUCTION: The evaluation of endothelial function has been performed in the arterial bed, but recently evaluation within the venous system has also been explored. Endothelial function studies employ different drugs that act as endothelium-dependent vasodilatory response inductors. OBJECTIVES: The aim of this study is to compare the endothelium-dependent venous vasodilator response mediated by either acetylcholine or bradykinin in healthy volunteers. METHODS AND RESULTS: Changes in vein diameter after phenylephrine-induced venoconstriction were measured to compare venodilation induced by acetylcholine or bradykinin (linear variable differential transformer dorsal hand vein technique). We studied 23 healthy volunteers; 31% were male, and the subject had a mean age of 33 ± 8 years and a mean body mass index of 23 ± 2 kg/m2. The maximum endothelium-dependent venodilation was similar for both drugs (p = 0.13), as well as the mean responses for each dose of both drugs (r = 0.96). The maximum responses to acetylcholine and bradykinin also had good agreement. CONCLUSION: There were no differences between acetylcholine and bradykinin as venodilators in this endothelial venous function investigation.
Contido em Clinics. São Paulo : Faculdade de Medicina, Universidade de São Paulo, 2008. Vol. 63, n. 5 (2008), p. 677-682
Assunto Acetilcolina
Bradicinina
[en] Acetylcholine
[en] Bradykinin
[en] Endothelium
[en] Vascular
[en] Veins
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/49782
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