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dc.contributor.authorMesquita, Marilise Oliveirapt_BR
dc.contributor.authorRamos, Ana Regina Limapt_BR
dc.contributor.authorWinkelmann, Leonardo Voglinopt_BR
dc.contributor.authorMatte, Ursula da Silveirapt_BR
dc.contributor.authorGoldani, Helena Ayako Suenopt_BR
dc.contributor.authorSilveira, Themis Reverbel dapt_BR
dc.date.accessioned2012-06-29T01:32:38Zpt_BR
dc.date.issued2006pt_BR
dc.identifier.issn1677-5538pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/49850pt_BR
dc.description.abstractObjective: Analyze the changes in the seminiferous epithelium in rats with carbon tetrachloride-induced cirrhosis (CCl4). Materials and Methods: Forty-eight male Wistar rats aged 45-50 days, weighing 150-180 grams were used. Twenty-two rats underwent CCl4-induced cirrhosis with CCl4 0.25 mL/Kg weekly intragastrically once a week, during 10 weeks. Additionally, they had a 44% food restriction diet (Group 1). The control group was divided in two subgroups: 13 rats had a 44% food restriction diet and no CCl4 (Group 2) and 10 rats were not submitted to CCl4 or food restriction (Group 3). After 10 weeks, the rats were sacrificed and liver sections were collected for histological analysis. The testicular analysis was carried out to evaluate the frequency of tubules in stages VIII and XIV. Results: The mean rates of stage VIII in animals with food restriction plus CCl4-induced cirrhosis and food restriction without CCl4 were significantly different from animals without either food restriction or CCl4 (18.1 ± 5.5%, 20.5 ± 2.5% and 13.4 ± 3.5%, respectively, p = 0.002). The mean rate of stage VIII in rats with cirrhosis was not significantly different from rats without cirrhosis (18.1 ± 5.5% and 17.4 ± 4.6% respectively). The mean frequency of stage XIV in rats with cirrhosis was significantly greater than rats without cirrhosis (4.7 ± 2.3% and 6.8 ± 1.9% respectively, p = 0.027). Conclusion: Animals with CCl4-induced cirrhosis and food restriction have shown alterations in spermatogenic cycle that were not seen in rats without CCl4-induced cirrhosis and food restriction.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofInternational braz j urol. Vol. 32, n. 1 (jan./feb. 2006), p. 94-99pt_BR
dc.rightsOpen Accessen
dc.subjectRatospt_BR
dc.subjectRatsen
dc.subjectCirrose hepáticapt_BR
dc.subjectLiver cirrhosisen
dc.subjectExperimentalen
dc.subjectTetracloreto de carbonopt_BR
dc.subjectPrivação de alimentospt_BR
dc.subjectCarbon tetrachlorideen
dc.subjectFood deprivationen
dc.subjectEspermatogênesept_BR
dc.subjectSpermatogenesisen
dc.titleSeminiferous epithelium of rats with food restriction and carbon tetrachloride-induced cirrhosispt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000567014pt_BR
dc.type.originNacionalpt_BR


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