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Biocompatibility of RealSeal, its primer and AH Plus implanted in subcutaneous connective tissue of rats

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Biocompatibility of RealSeal, its primer and AH Plus implanted in subcutaneous connective tissue of rats

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Título Biocompatibility of RealSeal, its primer and AH Plus implanted in subcutaneous connective tissue of rats
Autor Grecca, Fabiana Soares
Kopper, Patrícia Maria Poli
Santos, Regis Burmeister dos
Fossati, Anna Christina Medeiros
Carrard, Vinícius Coelho
Acasigua, Gerson Arisoly Xavier
Figueiredo, Jose Antonio Poli de
Abstract Objective: This study tested rat connective tissue response to RealSeal, RealSeal primer or AH Plus after 7, 15, 30, 60 and 90 days of implantation. Material and methods: Thirty Wistar rats had subcutaneous sockets created on their back and received four implants each of polyethylene tubes containing one of the materials tested according to the groups: AH (AH Plus Sealer); RS (RealSeal Sealer); RP (RealSeal Primer); CG (control group – empty tube). After histological processing, sections were analyzed to identify the presence of neutrophils, lymphocytes and plasma cells, eosinophils, macrophages and giant cells, as well as fibrous capsule and abscesses, by and examiner using light microscope. Kruskal-Wallis and multiple-comparisions test were used for statistical analysis. Significance level was set at 5%. Results: Lymphoplasmacytic infiltrate scores significantly higher than those of the control group were observed at 14 and 60 days in AH group, and at 90 days in RS group (p<0.05). There were no differences in terms of presence of macrophages, giant cells, eosinophils, neutrophils or fibrosis. AH Plus group scored higher for abscesses at 7 days than after any other period (p=0.031). RP group scored higher for lymphoplasmacytic infiltrate at 14 days than 90 days (p=0.04). Conclusion: the main contribution of this study was to demonstrate that issues involved with tissue tolerance of a Resilon-containing sealer, RealSeal Sealer, cannot be attributed to its primer content.
Contido em Journal of applied oral science. Bauru. Vol. 19, no. 1 (Jan./Feb. 2011), p. 52-56
Assunto Endodontia
Materiais biocompativeis
Materiais odontologicos : Avaliacao
Tela subcutânea
[en] Biocompatible materials
[en] Endodontics
[en] Root canal filling materials
[en] Subcutaneous tissue
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/61198
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