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Essential oil from leaves of Lantana camara : a potential source of medicine against leishmaniasis

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Essential oil from leaves of Lantana camara : a potential source of medicine against leishmaniasis

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Título Essential oil from leaves of Lantana camara : a potential source of medicine against leishmaniasis
Autor Machado, Raquel R.P.
Valente Junior, Wilson
Lesche, Bernhard
Coimbra, Elaine S.
Souza, Nicolli B.de
Abramo, Clarice
Soares, Geraldo Luiz Gonçalves
Kaplan, Maria Auxiliadora Coelho
Resumo Leishmaniasis is an infection of viscera or tegument caused by protozoa Leishmania sp. The extensive period required for the treatment, which involves the use of toxic medicines, leads patients to drop treatment increasing the development of resistant forms of Leishmania sp. Lantana camara L., Verbenaceae, is a tropical plant native from America. Folk uses have been described for treatment of tumors, tetanus, rheumatism and malaria. This study evaluates the leishmanicidal activity of the essential oil of leaves from L. camara on promastigote forms of Leishmania chagasi and L. amazonensis and its toxic effects on Artemia salina (brine shrimp test), macrophage cultures and BALB/c mice. The chemical composition was evaluated using the gas chromatography coupled with mass spectrometer (GC-MS). Thirty substances, mostly mono and sesquiterpenes were identifi ed. The most representative constituents were: germacrene D (24.90%), farnesene derivatives (22%) and (E)-cariophylene (14.31%). Bioassays revealed a signifi cant leishmanicidal activity of essential oil against L. amazonensis (IC50 0.25 μg/ mL) and a potential toxic effect on Brine shrimp (LC50 10 μg/mL) and macrophage assays (CC50 4 μg/mL), while there was no toxic manifestation on mice. The data show the relevant potential of L. camara as a source of medicine for leishmaniasis treatment.
Contido em Revista brasileira de farmacognosia. São Paulo. Vol. 22, N. 5, (set./out. 2012), p. 1011-1017
Assunto Biotecnologia vegetal
Plantas medicinais
Verbenaceae
[en] Farnesene
[en] Germacrene-D
[en] Leishmania amazonensis
[en] Leishmania chagasi
[en] Toxicity
[en] Volatiles
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/72304
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