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Evidence of a relationship between aversive learning and hippocampal interleukin 1 beta levels in neonatal handled rats

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Evidence of a relationship between aversive learning and hippocampal interleukin 1 beta levels in neonatal handled rats

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Título Evidence of a relationship between aversive learning and hippocampal interleukin 1 beta levels in neonatal handled rats
Autor Nunes, Wagner de Paula
Orientador Lucion, Aldo Bolten
Co-orientador Rocha, Cláudio Felipe Kolling da
Data 2012
Nível Graduação
Instituição Universidade Federal do Rio Grande do Sul. Instituto de Ciências Básicas da Saúde. Curso de Biomedicina.
Assunto Aprendizagem da esquiva
Hipocampo
Interleucina-1
Manipulação neonatal
Sistema nervoso central
[en] Hippocampus
[en] IL-1 b
[en] Inhibitory avoidance
[en] Interleukin 1 beta
[en] Neonatal handling
Resumo The Neonatal Handling (NH) model presents a “blunted” corticosterone response to stress as well as an enhancement in contextual fear tasks. So the aim of this work was to examine a possible relationship between diminished imunosuppression over Interleukin 1 beta (IL-1) hippocampal levels and enhancement in aversive learning. To achieve that, we subjected male handled Wistar rats 30-35 and 90 days old to an inhibitory avoidance task, comparing the avoidance scores with respective hippocampal IL-1 levels at different time points. We found that handled adult animals learned the aversive task concomitantly with higher levels of hippocampal interleukin 1 beta 2h after footshock, while control animals showed diminished aversive learning and lower IL-1 beta levels at the same time. In the other hand, both handled and non-handled juvenile rats learned the aversive task, with no signal of immunosuppressant efect over interleukin 1 beta. However, basal levels of IL-1 beta were different between handled and non-handled animals in both ages, pointing a novel neuroimmunomodulation involvement to the NH model.
Tipo Trabalho de conclusão de graduação
URI http://hdl.handle.net/10183/72411
Arquivos Descrição Formato
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