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Nanoparticle-coated organic-inorganic microparticles : experimental design and gastrointestinal tolerance evaluation

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Nanoparticle-coated organic-inorganic microparticles : experimental design and gastrointestinal tolerance evaluation

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Título Nanoparticle-coated organic-inorganic microparticles : experimental design and gastrointestinal tolerance evaluation
Autor Beck, Ruy Carlos Ruver
Haas, Sandra Elisa
Guterres, Silvia Stanisçuaski
Ré, Maria Inês
Benvenutti, Edilson Valmir
Pohlmann, Adriana Raffin
Abstract The influences of the spray-drying parameters and the type of nanoparticles (nanocapsules or nanospheres) on the characteristics of nanoparticle-coated diclofenac-loaded microparticles were investigated by using a factorial design 32. Gastrointestinal tolerance following oral administration in rats was evaluated. Formulations were selected considering the best yields, the best encapsulation efficiencies and the lowest water contents, presenting surfaces completely coated by nanostructures and a decrease in the surface areas in relation to the uncoated core. In vitro drug release demonstrated the influence of the nanoparticle-coating on the dissolution profiles of diclofenac. Nanocapsule-coated microparticles presented a protective effect on the gastrointestinal mucosa.
Contido em Química nova. Vol. 29, n.5 (Sept./Oct. 2006), p. 990-996
Assunto Microparticulas
Nanoesferas
[en] Microparticle
[en] Nanocoating
[en] Nanoparticle
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/72853
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