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High performance liquid chromatography method for quantification of the n-phenylpiperazine derivative lassbio-579 in rat plasma

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High performance liquid chromatography method for quantification of the n-phenylpiperazine derivative lassbio-579 in rat plasma

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Título High performance liquid chromatography method for quantification of the n-phenylpiperazine derivative lassbio-579 in rat plasma
Autor Conrado, Daniela Joice
Rates, Stela Maris Kuze
Dalla Costa, Teresa Cristina Tavares
Fraga, Carlos Alberto Manssour
Barreiro, Eliezer J.
Abstract A rapid HPLC analytical method was developed and validated for the determination of the N-phenylpiperazine derivative LASSBio- 579 in plasma rat. Analyses were performed using a C18 column and elution with 20 mM sodium dihydrogen phosphate monohydrate-methanol. The analyte was monitored using a photodiode array detector (257 nm). Calibration curves in spiked plasma were linear over the concentration range of 0.3-8 μg/mL with determination coefficient > 0.99. The lower limit of quantification was 0.3 μg/mL. The applicability of the HPLC method for pharmacokinetic studies was tested using plasma samples obtained after administration of LASSBio-579 to Wistar rats, showing the specificity of the method.
Contido em Química nova. São Paulo. Vol. 30, n. 8 (2007), p. 1019-1922
Assunto Cromatografia liquida de alta eficiencia (clae)
Farmacocinética
LASSBio-579
[en] HPLC
[en] LASSBio-579
[en] Pharmacokinetics
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/72862
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