Uv derivative spectrophotometric method for determination of estradiol valerate in tablets
dc.contributor.author | Mendez, Andreas Sebastian Loureiro | pt_BR |
dc.contributor.author | Deconto, Lislaine | pt_BR |
dc.contributor.author | Garcia, Cassia Virginia | pt_BR |
dc.date.accessioned | 2013-07-02T01:43:27Z | pt_BR |
dc.date.issued | 2010 | pt_BR |
dc.identifier.issn | 0100-4042 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/72896 | pt_BR |
dc.description.abstract | A derivative UV spectrophotometric method for determination of estradiol valerate in tablets was validated. The parameters specificity, linearity, precision, accuracy, limit of detection and limit of quantitation were studied according to validation guidelines. The first-order derivative spectra were obtained at N = 5, Δλ = 4.0 nm, and determinations were made at 270 nm. The method showed specificity and linearity in the concentration range of 0.20 to 0.40 mg mL-1. The intra and interday precision data demonstrated the method has good reproducibility. Accuracy was also evaluated and results were satisfactory. The proposed method was successfully applied to a pharmaceutical formulation. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Química nova. São Paulo. Vol. 33, n. 4 (2010), p. 981-983 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Estradiol valerate | en |
dc.subject | Estradiol | pt_BR |
dc.subject | Validação : Métodos de análise de fármacos | pt_BR |
dc.subject | UV derivative spectrophotometric method | en |
dc.subject | Method validation | en |
dc.subject | Espectrofotometria ultravioleta | pt_BR |
dc.title | Uv derivative spectrophotometric method for determination of estradiol valerate in tablets | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000793483 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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