Repositório Digital

A- A A+

Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorder

.

Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorder

Mostrar registro completo

Estatísticas

Título Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorder
Autor Chiarani, Fabria
Tramontina, Juliana Fernandes
Ceresér, Keila Maria Mendes
Kunz, Maurício
Paim, Leonardo Ludwig
Vargas, Carmen Regla
Sitta, Angela
Machado, Sérgio Carlos Eduardo Pinto
Wyse, Angela Terezinha de Souza
Kapczinski, Flávio Pereira
Abstract Objective: To evaluate serum levels of different biomarkers associated with cardiovascular disease in patients with bipolar disorder (BD). Patients were prospectively evaluated in two separate instances: during acute mania and after remission of manic symptoms. All measurements were compared with those of healthy controls. Methods: The study included 30 patients with BD and 30 healthy controls, matched for gender and age. Biochemical parameters evaluated included homocysteine (Hcy), folic acid, vitamin B12, ferritin, creatine kinase (CK) and C-reactive protein (CRP). Results: Hcy levels were significantly higher in the BD patients, both during mania and after achieving euthymia. When Hcy was adjusted for body mass index, there was no significant difference between patients and controls. Ferritin was the only marker that showed a significant decrease during mania when compared to both euthymic patients and controls. There were no significant differences for folate, vitamin B12, CK and CRP. Conclusions: These findings do not show an association between alterations of markers of cardiovascular risk during manic episodes. Further studies are necessary to determine factors and mechanisms associated with cardiovascular risk in patients with BD.
Contido em Revista brasileira de psiquiatria (1999). Vol. 35, no. 2 (abr./jun. 2013), p. 157-160
Assunto Doenças cardiovasculares : Diagnóstico
Ferritinas
Homocisteína
Transtorno bipolar
[en] Bipolar disorder
[en] Cardiovascular disease
[en] Ferritin
[en] Homocysteine
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/80327
Arquivos Descrição Formato
000904787.pdf (58.83Kb) Texto completo (inglês) Adobe PDF Visualizar/abrir

Este item está licenciado na Creative Commons License

Este item aparece na(s) seguinte(s) coleção(ões)


Mostrar registro completo

Percorrer



  • O autor é titular dos direitos autorais dos documentos disponíveis neste repositório e é vedada, nos termos da lei, a comercialização de qualquer espécie sem sua autorização prévia.
    Projeto gráfico elaborado pelo Caixola - Clube de Criação Fabico/UFRGS Powered by DSpace software, Version 1.8.1.