Repositório Digital

A- A A+

Homo sapiens, Homo neanderthalensis and the Denisova specimen : New insights on their evolutionary histories using whole-genome comparisons

.

Homo sapiens, Homo neanderthalensis and the Denisova specimen : New insights on their evolutionary histories using whole-genome comparisons

Mostrar registro completo

Estatísticas

Título Homo sapiens, Homo neanderthalensis and the Denisova specimen : New insights on their evolutionary histories using whole-genome comparisons
Autor Paixão Côrtes, Vanessa Rodrigues
Viscardi, Lucas Henriques
Salzano, Francisco Mauro
Hunemeier, Tábita
Bortolini, Maria Cátira
Abstract After a brief review of the most recent findings in the study of human evolution, an extensive comparison of the complete genomes of our nearest relative, the chimpanzee (Pan troglodytes), of extant Homo sapiens, archaic Homo neanderthalensis and the Denisova specimen were made. The focus was on non-synonymous mutations, which consequently had an impact on protein levels and these changes were classified according to degree of effect. A total of 10,447 non-synonymous substitutions were found in which the derived allele is fixed or nearly fixed in humans as compared to chimpanzee. Their most frequent location was on chromosome 21. Their presence was then searched in the two archaic genomes. Mutations in 381 genes would imply radical amino acid changes, with a fraction of these related to olfaction and other important physiological processes. Eight new alleles were identified in the Neanderthal and/or Denisova genetic pools. Four others, possibly affecting cognition, occured both in the sapiens and two other archaic genomes. The selective sweep that gave rise to Homo sapiens could, therefore, have initiated before the modern/archaic human divergence.
Contido em Genetics and molecular biology. Ribeirão Preto, SP. Vol. 35, n. 4 supl (2012), p. 904-911
Assunto Denisova
Evolução humana
Genômica
Homo sapiens
Neandertal
Seleção natural
[en] comparative genomics
[en] Denisova
[en] human evolution
[en] Neanderthal
[en] positive selection
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/87817
Arquivos Descrição Formato
000871249.pdf (559.9Kb) Texto completo Adobe PDF Visualizar/abrir

Este item está licenciado na Creative Commons License

Este item aparece na(s) seguinte(s) coleção(ões)


Mostrar registro completo

Percorrer



  • O autor é titular dos direitos autorais dos documentos disponíveis neste repositório e é vedada, nos termos da lei, a comercialização de qualquer espécie sem sua autorização prévia.
    Projeto gráfico elaborado pelo Caixola - Clube de Criação Fabico/UFRGS Powered by DSpace software, Version 1.8.1.