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dc.contributor.authorPretto, Luanapt_BR
dc.contributor.authorParis, Fernanda dept_BR
dc.contributor.authorMachado, Alice Beatriz Mombach Pinheiropt_BR
dc.contributor.authorMartins, Andreza Franciscopt_BR
dc.contributor.authorBarth, Afonso Luispt_BR
dc.date.accessioned2014-02-28T01:50:26Zpt_BR
dc.date.issued2013pt_BR
dc.identifier.issn1413-8670pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/87932pt_BR
dc.description.abstractBurkholderia cenocepacia may cause serious infections in patients with cystic fibrosis, and this microorganism can be highly transmissible. Pulsed-field gel electrophoresis is widely used to study the dynamics of strain spread in cystic fibrosis patients. The aim of this work was to perform pulsed-field gel electrophoresis-based molecular typing of B. cenocepacia isolates to evaluate the epidemiology of this species at our hospital. A total of 28 isolates from 23 cystic fibrosis patients were analyzed. Initially, we compared isolates obtained from the same patient at different periods of time. We then compared the pulsed-field gel electrophoresis profiles of 15 IIIA isolates, and in a third analysis, evaluated the genetic profile of 8 IIIB isolates from different patients. The pulsed-field gel electrophoresis profiles of isolates from the same patient indicated that they are genetically indistinguishable. Analysis of isolates from different patients revealed the presence of multiple clonal groups. These results do not indicate cross-transmission of a unique clone of B. cenocepacia among cystic fibrosis patients, although this has been observed in some patients. Our findings highlight the importance of adequate patient follow-up at cystic fibrosis centers and adherence to management and segregation measures in cystic fibrosis patients colonized with B. cenocepacia.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofThe Brazilian journal of infectious diseases. Vol. 17, no. 1 (2013), p. 86-89pt_BR
dc.rightsOpen Accessen
dc.subjectBurkholderia cepaciapt_BR
dc.subjectInfecções por Burkholderiapt_BR
dc.subjectFibrose císticapt_BR
dc.subjectEletroforese em gel de campo pulsadopt_BR
dc.titleGenetic similarity of Burkholderia cenocepacia from cystic fibrosis patientspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000894315pt_BR
dc.type.originEstrangeiropt_BR


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