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Linking dopamine neurotransmission and neurogenesis: the evolutionary history of the NTAD (NCAM1-TTC12-ANKK1-DRD2) gene cluster

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Linking dopamine neurotransmission and neurogenesis: the evolutionary history of the NTAD (NCAM1-TTC12-ANKK1-DRD2) gene cluster

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Título Linking dopamine neurotransmission and neurogenesis: the evolutionary history of the NTAD (NCAM1-TTC12-ANKK1-DRD2) gene cluster
Autor Mota, Nina Roth
Araújo Júnior, Eli Vieira
Paixão Côrtes, Vanessa Rodrigues
Bortolini, Maria Cátira
Bau, Claiton Henrique Dotto
Abstract Genetic studies have long suggested the important role of theDRD2 gene in psychiatric disorders and behavior. Further research has shown a conjoined effect of genes in the Chr11q22-23 region, which includes theNCAM1, TTC12, ANKK1 and DRD2 genes, or NTAD cluster. Despite a growing need to unravel the role of this cluster, few studies have taken into account interspecies and evolutionary approaches. This study shows that behaviorally relevant SNPs from the NTAD cluster, such as rs1800497 (Taq1A) and rs6277, are ancient polymorphisms that date back to the common ancestor between modern humans and Neanderthals/Denisovans. Conserved synteny and neighborhood indicate the NTAD cluster seems to have been established at least 400 million years ago, when the first Sarcopterygians emerged. The NTAD genes are apparently co-regulated and this could be attributed to adaptive functional properties, including those that emerged when the central nervous system became more complex. Finally, our findings indicate that NTAD genes, which are related to neurogenesis and dopaminergic neurotransmission, should be approached as a unit in behavioral and psychiatric genetic studies.
Contido em Genetics and molecular biology. Ribeirão Preto, SP. Vol. 35, n. 4 supl (2012), p. 912-918
Assunto Dopamina
Neurogênese
Neurotransmissores
Psiquiatria
Transtornos mentais
[en] co-regulation
[en] NTAD cluster
[en] psychiatric genetics
[en] shared synteny
[en] Taq1A SNP
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/87951
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