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dc.contributor.authorMota, Nina Rothpt_BR
dc.contributor.authorAraújo Júnior, Eli Vieirapt_BR
dc.contributor.authorPaixão Côrtes, Vanessa Rodriguespt_BR
dc.contributor.authorBortolini, Maria Cátirapt_BR
dc.contributor.authorBau, Claiton Henrique Dottopt_BR
dc.date.accessioned2014-02-28T01:50:33Zpt_BR
dc.date.issued2012pt_BR
dc.identifier.issn1415-4757pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/87951pt_BR
dc.description.abstractGenetic studies have long suggested the important role of theDRD2 gene in psychiatric disorders and behavior. Further research has shown a conjoined effect of genes in the Chr11q22-23 region, which includes theNCAM1, TTC12, ANKK1 and DRD2 genes, or NTAD cluster. Despite a growing need to unravel the role of this cluster, few studies have taken into account interspecies and evolutionary approaches. This study shows that behaviorally relevant SNPs from the NTAD cluster, such as rs1800497 (Taq1A) and rs6277, are ancient polymorphisms that date back to the common ancestor between modern humans and Neanderthals/Denisovans. Conserved synteny and neighborhood indicate the NTAD cluster seems to have been established at least 400 million years ago, when the first Sarcopterygians emerged. The NTAD genes are apparently co-regulated and this could be attributed to adaptive functional properties, including those that emerged when the central nervous system became more complex. Finally, our findings indicate that NTAD genes, which are related to neurogenesis and dopaminergic neurotransmission, should be approached as a unit in behavioral and psychiatric genetic studies.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofGenetics and molecular biology. Ribeirão Preto, SP. Vol. 35, n. 4 supl (2012), p. 912-918pt_BR
dc.rightsOpen Accessen
dc.subjectNTAD clusteren
dc.subjectNeurotransmissorespt_BR
dc.subjectDopaminapt_BR
dc.subjectTaq1A SNPen
dc.subjectshared syntenyen
dc.subjectNeurogênesept_BR
dc.subjectPsiquiatriapt_BR
dc.subjectco-regulationen
dc.subjectTranstornos mentaispt_BR
dc.subjectpsychiatric geneticsen
dc.titleLinking dopamine neurotransmission and neurogenesis: the evolutionary history of the NTAD (NCAM1-TTC12-ANKK1-DRD2) gene clusterpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000871430pt_BR
dc.type.originNacionalpt_BR


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