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New evidence for balancing selection at the HLA-G locus in south amerindians

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New evidence for balancing selection at the HLA-G locus in south amerindians

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Título New evidence for balancing selection at the HLA-G locus in south amerindians
Autor Veit, Tiago Degani
Cazarolli, Juciana Clarice
Salzano, Francisco Mauro
Schiengold, Marion
Chies, Jose Artur Bogo
Abstract HLA-G is a non-classical HLA (Human Leukocyte Antigen) molecule characterized by limited tissue distribution under normal physiological conditions and low variability at both DNA and protein levels. Several studies suggest that HLA-G could play a role, as an immunoregulatory molecule, in situations as diverse as transplantation, cancer, viral infections and inflammatory diseases. A total of 237 individuals from 21 South American tribes speaking nine different linguistic families were studied in relation to the 14 bp insertion/deletion polymorphism at the HLA-G gene. A consistent (seven in nine) excess of heterozygosity in samples classified by language was obtained. Our data supply evidences for balancing selection acting at the HLA-G 14 bp INDEL region. Enhanced fetal survival in a pathogen- rich environment may account for these findings.
Contido em Genetics and molecular biology. Vol. 35, n. 4 supl (Dec. 2012), p. 919-923
Assunto Genética
[en] Amerindians
[en] balancing selection
[en] HLA-G 14 bp INDEL
[en] pathogen resistance
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/87995
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