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The brazilian contribution to attention-deficit/hyperactivity disorder molecular genetics in children and adolescents

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The brazilian contribution to attention-deficit/hyperactivity disorder molecular genetics in children and adolescents

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Título The brazilian contribution to attention-deficit/hyperactivity disorder molecular genetics in children and adolescents
Autor Genro, Júlia Pasqualini
Roman, Tatiana
Rohde, Luis Augusto Paim
Hutz, Mara Helena
Abstract Attention-Deficit/Hyperactivity Disorder (ADHD) is a common psychiatric condition of children worldwide. This disorder is defined by a combination of symptoms of inattention and hyperactivity/impulsivity. Diagnosis is based on a sufficient number of symptoms causing impairment in these two domains determining several problems in personal and academic life. Although genetic and environmental factors are important in ADHD etiology, how these factors influence the brain and consequently behavior is still under debate. It seems to be consensus that a fronto-subcortical dysfunction is responsible, at least in part, for the ADHD phenotype spectrum. The main results from association and pharmacogenetic studies performed in Brazil are discussed. The investigations performed so far on ADHD genetics in Brazil and elsewhere are far from conclusive. New plausible biological hypotheses linked to neurotransmission and neurodevelopment, as well as new analytic approaches are needed to fully disclose the genetic component of the disorder.
Contido em Genetics and molecular biology. Ribeirão Preto. Vol. 35, n. 4 supl (Dec. 2012), p. 932-938
Assunto Adolescente
Criança
Genética
Patologia molecular
Transtorno do déficit de atenção com hiperatividade
[en] ADHD
[en] candidate genes
[en] pharmacogenetics
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/87999
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