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Conventional serological performance in diagnosis of Chagas’ disease in southern Brazil

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Conventional serological performance in diagnosis of Chagas’ disease in southern Brazil

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Título Conventional serological performance in diagnosis of Chagas’ disease in southern Brazil
Autor Araujo, Anelise Bergmann
Berne, Maria Elisabeth Aires
Abstract Results of Chagas’ disease diagnosis show disagreement. The aim of this study was to compare commercial tests for Chagas’ disease serodiagnosis in southern Brazil. A total of 161 samples were evaluated. Three enzyme-linked immunosorbent assays, one indirect hemagglutination and one indirect immunofluorescence were assessed. Trypomastigote excreted-secreted antigen-blot was a confirmatory method. From 161 samples, 65.84% were positive in all tests, while 34.16% presents mismatch result in at least one of the tests. All techniques tested presented false-positive and/or false-negative results as follows: Enzyme-linked immunosorbent assay 1 had more false-positive results (lower specificity), indirect immunofluorescence had the highest rate of false-negative results (lower sensitivity), enzyme-linked immunosorbent assays had fewer false-negative results (higher sensitivity), while indirect hemagglutination showed no false-positive result (higher specificity). Knowing the characteristics of techniques make it possible to combine them and obtain more reliable diagnosis. Therefore, it seems useful to combine techniques for diagnosing this infection.
Contido em Brazilian journal of infectious diseases. Salvador. Vol. 17, n. 2 (2013), p. 174-178
Assunto Doença de Chagas
Imunoensaio
Testes sorológicos
Trypanosoma cruzi
[en] Chagas’ disease
[en] Serodiagnosis Immunoassays
[en] Trypanosoma cruzi
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/88125
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