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dc.contributor.authorContri, Renata Vidorpt_BR
dc.contributor.authorFrank, Luiza Abrahãopt_BR
dc.contributor.authorKaiser, Moacirpt_BR
dc.contributor.authorPohlmann, Adriana Raffinpt_BR
dc.contributor.authorGuterres, Silvia Stanisçuaskipt_BR
dc.date.accessioned2014-03-26T01:51:14Zpt_BR
dc.date.issued2014pt_BR
dc.identifier.issn1178-2013pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/89718pt_BR
dc.description.abstractCapsaicin, a topical analgesic used in the treatment of chronic pain, has irritant properties that frequently interrupt its use. In this work, the effect of nanoencapsulation of the main capsaicinoids (capsaicin and dihydrocapsaicin) on skin irritation was tested in humans. Skin tolerance of a novel vehicle composed of chitosan hydrogel containing nonloaded nanocapsules (CH-NC) was also evaluated. The chitosan hydrogel containing nanoencapsulated capsaicinoids (CH-NC-CP) did not cause skin irritation, as measured by an erythema probe and on a visual scale, while a formulation containing free capsaicinoids (chitosan gel with hydroalcoholic solution [CH-ET-CP]) and a commercially available capsaicinoids formulation caused skin irritation. Thirty-one percent of volunteers reported slight irritation one hour after application of CH-NC-CP, while moderate (46% [CH-ET-CP] and 23% [commercial product]) and severe (8% [CH-ET-CP] and 69% [commercial product]) irritation were described for the formulations containing free capsaicinoids. When CH-NC was applied to the skin, erythema was not observed and only 8% of volunteers felt slight irritation, which demonstrates the utility of the novel vehicle. A complementary in vitro skin permeation study showed that permeation of capsaicinoids through an epidermal human membrane was reduced but not prevented by nanoencapsulation.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofInternational Journal of Nanomedicine. Auckland. Vol. 9, no. 1 (Feb. 2014), p. 951-962pt_BR
dc.rightsOpen Accessen
dc.subjectChitosanen
dc.subjectNanocápsulaspt_BR
dc.subjectQuitosanapt_BR
dc.subjectNanocapsulesen
dc.subjectCapsaicinoidsen
dc.subjectSkin irritationen
dc.subjectSkin permeationen
dc.titleThe use of nanoencapsulation to decrease human skin irritation caused by capsaicinoidspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000912068pt_BR
dc.type.originEstrangeiropt_BR


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