Repositório Digital

A- A A+

Determination of germ tube, phospholipase, and proteinase production by bloodstream isolates of Candida albicans

.

Determination of germ tube, phospholipase, and proteinase production by bloodstream isolates of Candida albicans

Mostrar registro completo

Estatísticas

Título Determination of germ tube, phospholipase, and proteinase production by bloodstream isolates of Candida albicans
Autor Mattei, Antonella Souza
Alves, Sydney Hartz
Severo, Cecília Bittencourt
Guazzelli, Luciana Silva
Oliveira, Flávio de Mattos
Severo, Luiz Carlos
Abstract Candida albicans is a commensal and opportunistic agent that causes infection in immunocompromised individuals. Several attributes contribute to the virulence and pathogenicity of this yeast, including the production of germ tubes (GTs) and extracellular hydrolytic enzymes, particularly phospholipase and proteinase. This study aimed to investigate GT production and phospholipase and proteinase activities in bloodstream isolates of C. albicans. Methods: One hundred fi fty-three C. albicans isolates were obtained from blood samples and analyzed for GT, phospholipase, and proteinase production. The assays were performed in duplicate in egg yolk medium containing bovine serum albumin and human serum. Results: Detectable amounts of proteinase were produced by 97% of the isolates, and 78% of the isolates produced phospholipase. GTs were produced by 95% of the isolates. A majority of the isolates exhibited low levels of phospholipase production and high levels of proteinase production. Conclusions: Bloodstream isolates of C. albicans produce virulence factors such as GT and hydrolytic enzymes that enable them to cause infection under favorable conditions.
Contido em Revista da Sociedade Brasileira de Medicina Tropical. Brasilia. Vol. 46, n. 3 (maio/jun. 2013), p. 340-342
Assunto Candida albicans
Candidemia
Fosfolipases
Peptídeo hidrolases
Virulência
[en] Candida albicans
[en] Candidemia
[en] Germ tube
[en] Phospholipase
[en] Proteinase
[en] Virulence
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/94965
Arquivos Descrição Formato
000898157.pdf (676.8Kb) Texto completo Adobe PDF Visualizar/abrir

Este item está licenciado na Creative Commons License

Este item aparece na(s) seguinte(s) coleção(ões)


Mostrar registro completo

Percorrer



  • O autor é titular dos direitos autorais dos documentos disponíveis neste repositório e é vedada, nos termos da lei, a comercialização de qualquer espécie sem sua autorização prévia.
    Projeto gráfico elaborado pelo Caixola - Clube de Criação Fabico/UFRGS Powered by DSpace software, Version 1.8.1.