Repositório Digital

A- A A+

Effect of laser phototherapy in the prevention and treatment of chemo-induced mucositis in hamsters

.

Effect of laser phototherapy in the prevention and treatment of chemo-induced mucositis in hamsters

Mostrar registro completo

Estatísticas

Título Effect of laser phototherapy in the prevention and treatment of chemo-induced mucositis in hamsters
Autor Lopez, Talita Christine Camilo
Martins, Manoela Domingues
Pavesi, Vanessa Christina Santos
Ferreira, Leila Soares
Bussadori, Sandra Kalil
Moreira, Maria Stella Nunes Araújo
Marques, Márcia Martins
Abstract The aim of this study was to investigate the effect of laser phototherapy (LPT) in the prevention and/or treatment of oral mucositis induced by 5-fluorouracil (5-FU; Eurofarma, São Paulo, Brazil) in hamsters. Ninety-six hamsters were divided into four groups (n = 24): Control (no treatment); Preventive [LPT from day (D) D−5 to D+5]; Therapeutic (LPT from D+5 to D+15); and Combined (preventive plus therapeutic LPT from D−5 to D+15). The animals received an intraperitoneal injection of 5-FU on Days 0 and 2. The pouch mucosa was scratched on Days 3 and 4. The irradiation parameters were: indium-gallium-aluminum- phosphide (InGaAlP) diode laser (MM Optics, São Carlos, Brazil) (660 nm), beam area of 0.036 cm², 40 mW, 1.11 W/cm², 6.6 J/cm², power density applied daily of 39.6 J/cm², in punctual mode (six points and six seconds per point) and contact mode, one application per day. The animals were sacrificed on Days 0, 5, 10 and 15 (n = 6) and weighed, and the pouch mucosa was removed for histopathological analysis. Clinical and corresponding histological scores were compared using ANOVA and Tukey’s test (p ≤ 0.05). Similar weight losses ranging from 5% to 10% occurred in all groups. The therapeutic group had significantly lower clinical and histological scores than the other groups at Day 10. This study showed that positive effects on oral mucositis management were obtained only when LPT was applied in the therapeutic protocol (from D+5 to D+15 after chemotherapy).
Contido em Brazilian oral research. São Paulo. Vol. 27, n. 4 (jul./ago. 2013), p. 342-348
Assunto Laser na odontologia
Mucosa bucal : Doencas
Radioterapia
[en] Lasers
[en] Radiotherapy
[en] Stomatitis
[en] Therapeutics
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/94998
Arquivos Descrição Formato
000896920.pdf (3.355Mb) Texto completo Adobe PDF Visualizar/abrir

Este item está licenciado na Creative Commons License

Este item aparece na(s) seguinte(s) coleção(ões)


Mostrar registro completo

Percorrer



  • O autor é titular dos direitos autorais dos documentos disponíveis neste repositório e é vedada, nos termos da lei, a comercialização de qualquer espécie sem sua autorização prévia.
    Projeto gráfico elaborado pelo Caixola - Clube de Criação Fabico/UFRGS Powered by DSpace software, Version 1.8.1.