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The Val66Met polymorphism at the BDNF gene does not influence Wisconsin Card Sorting Test results in children and adolescents with bipolar disorder

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The Val66Met polymorphism at the BDNF gene does not influence Wisconsin Card Sorting Test results in children and adolescents with bipolar disorder

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Título The Val66Met polymorphism at the BDNF gene does not influence Wisconsin Card Sorting Test results in children and adolescents with bipolar disorder
Autor Zeni, Cristian Patrick
Tramontina, Silzá
Zeni, Thamis Aline
Coelho, Roberta Paula Schell
Pheula, Gabriel Ferreira
Bernardi, Julio Mocellin
Maldaner, Ursula
Silva, Talita Lopes
Oliveira, Angélica Salatino de
Hutz, Mara Helena
Rohde, Luis Augusto Paim
Abstract Objectives: To assess the role of the Val66Met polymorphism at the brain-derived neurotrophic factor (BDNF) gene on the performance of children and adolescents with bipolar disorder [juvenile bipolar disorder (JBD)] on the Wisconsin Card Sorting Test (WCST). Methods: Children and adolescents were assessed by the K-SADS-PL and a clinical evaluation for BD and comorbid conditions. Manic and depressive symptoms were assessed with the Young Mania Rating Scale and the Children Depression Rating Scale – Reviewed. The Val66Met polymorphism at the BDNF was genotyped from a blood sample. Patients’ IQ and executive functions were assessed by a standard cognitive flexibility test (WCST). Results: Fifty-three subjects were included in the study. No significant difference was observed between the Val/Val and Val/Met+Met/Met groups on any WCST scores in the MANCOVA (F48,5 = .76; p = .59; Perseverative Errors, p=.66; Nonperseverative Errors, p = .58; Categories Completed, p = .34; Attempts to Reach First Category, p=.64; and Percentage of Conceptual Level Responses, p = .99). Conclusions: Our findings from this sample of children and adolescents with BD do not replicate results from studies of adults and suggest the existence of differences in the neurobiology of this disorder across the life cycle. Investigations of larger samples are necessary to confirm these data.
Contido em Revista brasileira de psiquiatria (1999). São Paulo. Vol. 35, n. 1 (2013), p. 44-50
Assunto Adolescente
Criança
Fator neurotrófico derivado do encéfalo
Transtorno bipolar
[en] Adolescents
[en] BDNF
[en] Bipolar disorder
[en] Children
[en] Wisconsin card sorting test
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/95162
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