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Relationship between serum transforming growth factor ß1 and liver collagen content in rats treated with carbon tetrachloride

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Relationship between serum transforming growth factor ß1 and liver collagen content in rats treated with carbon tetrachloride

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Título Relationship between serum transforming growth factor ß1 and liver collagen content in rats treated with carbon tetrachloride
Outro título Relação entre fator transformador de crescimento β1 e conteúdo hepático de colágeno em ratos tratados com tetracloreto de carbono
Autor Oliveira, Fernanda dos Santos de
Silveira, Themis Reverbel da
Matte, Ursula da Silveira
Abstract Transforming Growth Factor ß1 (TGFß1) plays a fundamental role in fibrogenesis, although its importance as a biomarker of liver disease is still matter of debate. Objective - Quantify serum TGFß1 and its association to liver collagen content in rats exposed to Carbon Tetrachloride (CCl4). Methods - Rats were submitted to a fibrosis model using CCl4 and sacrificed after 6, 10, 12 and 16 weeks of treatment. Serum levels of TGFß1 were measured by ELISA and collagen content was defined by morphometric analysis. Results - Serum levels of TGFß1 increased between 6 and 10 weeks, whereas collagen density increased between 12 and 16 weeks. A negative correlation was observed between liver collagen deposition and serum levels of TGFß1 (r = -0.48; P<0.05). Conclusion - Serum levels of TGFß1 were inversely proportional to collagen intensity in cirrhotic livers of rats exposed to CCl4, thus suggesting a limited use as biomarker in advanced liver disease.
Contido em Arquivos de gastroenterologia = Archives of gastroenterology. Vol. 49, n. 3 (jul./set. 2012), p. 232-234
Assunto Carboneum chloratum
Cirrose hepática experimental
Fator transformador de crescimento beta1
Modelos animais de doenças
Tetracloreto de carbono
[en] Carbon Tetrachloride
[en] Collagen
[en] Liver cirrhosis, experimental
[en] Rats
[en] Transforming growth factor beta 1
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/95253
Arquivos Descrição Formato
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