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Diminished expression of complement regulatory proteins on peripheral blood cells from systemic lupus erythematosus patients

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Diminished expression of complement regulatory proteins on peripheral blood cells from systemic lupus erythematosus patients

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Título Diminished expression of complement regulatory proteins on peripheral blood cells from systemic lupus erythematosus patients
Autor Alegretti, Ana Paula
Schneider, Laiana
Piccoli, Amanda Kirchner
Monticielo, Odirlei André
Lora, Priscila Schmidt
Brenol, João Carlos Tavares
Xavier, Ricardo Machado
Abstract CD55, CD59, CD46, and CD35 are proteins with complement regulatory (Creg) properties that ensure cell and tissue integrity when this system is activated. The aim of this study was to evaluate the Creg expression on peripheral blood cells from SLE patients and its association with cytopenia and disease activity. Flow cytometric analyses were performed on blood cells from 100 SLE patients and 61 healthy controls. Compared with healthy controls, we observed in SLE patients with lymphopenia and neutropenia decreased expression of CD55, CD59, and CD46 (P < 0.05). In SLE patients with anemia, CD59 and CD35 were decreased on red blood cells. Furthermore, there was a negative correlation between CD55 and CD59 on neutrophils and the disease activity. The results suggest there is an altered pattern of Creg expression on the peripheral blood cells of SLE patients, and the expression is correlated with disease activity and/or with activation of the complement system.
Contido em Clinical and developmental immunology. Abingdon. Vol. 2012 (2012), ID 725684, [9] p.
Assunto Células sanguíneas
Lupus eritematoso sistêmico
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/96761
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