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Concomitance of IgM and IgG anti-dsDNA antibodies does not appear to associate to active lupus nephritis

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Concomitance of IgM and IgG anti-dsDNA antibodies does not appear to associate to active lupus nephritis

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Título Concomitance of IgM and IgG anti-dsDNA antibodies does not appear to associate to active lupus nephritis
Autor Keiserman, Briele
Ronchetti, Maria Rita
Monticielo, Odirlei André
Keisermann, Mauro
Staub, Henrique Luiz
Abstract Previous reports proposed that the IgM anti-dsDNA antibody is protective for lupus nephritis. In this crosssectional study, we aimed to compare clinical features of systemic lupus erythematosus (SLE) patients positive for IgG anti-dsDNA alone with those presenting both IgG and IgM anti-dsDNA. Anti-dsDNA antibodies, urinary examination and complement levels were assessed in the day of appointment. IgG and IgM anti-dsDNA antibodies were detected by indirect immunofluorescence. Fifty-eight SLE patients (93.1% female, 81% European-derived, mean age 42.8±14.7 years, mean duration of disease 10.9±8 years) positive for IgG anti-dsDNA entered the study. Of those, 15 were also positive for the IgM anti-dsDNA isotype. The group with both isotypes showed significant less frequency of active nephritis (sediment changes and proteinuria) when compared to patients with IgG anti-dsDNA alone (6.7% versus 34.9%, p=0.046). These data suggest a nephroprotective role for IgM anti-dsDNA and a distinct biologic behavior for this isotype in SLE.
Contido em Open rheumatology journal. Hilversum. Vol. 7 (Nov. 2013), p. 101-104
Assunto Lupus eritematoso sistêmico
Nefrite lúpica
[en] IgG and IgM anti-dsDNA antibodies
[en] Lupus nephritis
[en] Systemic lupus erythematosus
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/96787
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