Navegação por Autor "Pascoal, Tharick Ali"

Resultados 1-15 de 15

    • Amyloid-dependent and amyloid-independent effects of Tau in individuals without dementia 

      Therriault, Joseph; Pascoal, Tharick Ali; Sefranek, Marcus; Mathotaarachchi, Sulantha Sanjeewa; Benedet, Andréa L.; Chamoun, Mira; Lussier, Firoza Z.; Tissot, Cecile; Bellaver, Bruna; Ferreira, Pâmela Lukasewicz; Zimmer, Eduardo Rigon; Saha-Chaudhuri, Paramita; Gauthier, Serge G.; Rosa Neto, Pedro (2021) [Artigo de periódico]
      Objective: To investigate the relationship between the topography of amyloid-β plaques, tau neurofibrillary tangles, and the overlap between the two, with cognitive dysfunction in individuals without dementia. Methods: We ...

    • APOEε4 associates with microglial activation independently of Aβ plaques and tau tangles 

      Souza, João Pedro Ferrari; Souza, Diogo Onofre Gomes de; Zimmer, Eduardo Rigon; Pascoal, Tharick Ali (2023) [Artigo de periódico]
      Animal studies suggest that the apolipoprotein E ε4 (APOEε4) allele is a culprit of early microglial activation in Alzheimer’s disease (AD). Here, we tested the association between APOEε4 status and microglial activation ...

    • Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer’s disease 

      Souza, João Pedro Ferrari; Zimmer, Eduardo Rigon; Pascoal, Tharick Ali (2022) [Artigo de periódico]
      Astrocytes can adopt multiple molecular phenotypes in the brain of Alzheimer’s disease (AD) patients. Here, we studied the associations of cerebrospinal fluid (CSF) glial fibrillary acidic protein (GFAP) and chitinase-3-like ...

    • Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease 

      Bellaver, Bruna; Zimmer, Eduardo Rigon; Pascoal, Tharick Ali (2023) [Artigo de periódico]
      An unresolved question for the understanding of Alzheimer’s disease (AD) pathophysiology is why a significant percentage of amyloid-β (Aβ)-positive cognitively unimpaired (CU) individuals do not develop detectable downstream ...

    • Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's disease 

      Ashton, Nicholas J.; Benedet, Andréa L.; Pascoal, Tharick Ali; Karikari, Thomas K.; Lantero-Rodriguez, Juan; Brum, Wagner Scheeren; Mathotaarachchi, Sulantha Sanjeewa; Therriault, Joseph; Savard, Mélissa; Chamoun, Mira; Stoops, Erik; François, Cindy; Vanmechelen, Eugeen; Gauthier, Serge G.; Zimmer, Eduardo Rigon; Zetterberg, Henrik; Blennow, Kaj; Rosa Neto, Pedro (2022) [Artigo de periódico]
      Background: Phosphorylated tau (p-tau) epitopes in cerebrospinal fluid (CSF) are accurate biomarkers for a pathological and clinical diagnosis of Alzheimer's disease (AD) and are seen to be increased in preclinical stage ...

    • Cross-species comparative hippocampal transcriptomics in Alzheimer’s disease 

      De Bastiani, Marco Antônio; Bellaver, Bruna; Collar, Giovanna Carello; Zimmermann, Maria; Kunach, Peter; Lima Filho, Ricardo André Santana; Forner, Stefania; Martini, Alessandra Cadete; Pascoal, Tharick Ali; Lourenço, Mychael Vinícius da Costa; Rosa Neto, Pedro; Zimmer, Eduardo Rigon (2024) [Artigo de periódico]
      Alzheimer’s disease (AD) is a multifactorial pathology, with most cases having a sporadic origin. Recently, knock-in (KI) mouse models, such as the novel humanized amyloid-b (hAb)-KI, have been developed to better resemble ...

    • Dynamic amyloid and metabolic signatures of delayed recall performance within the clinical spectrum of Alzheimer’s disease 

      Dauar, Marina Tedeschi; Pascoal, Tharick Ali; Therriault, Joseph; Rowley, Jared; Mohaddes, Sara; Shin, Monica; Zimmer, Eduardo Rigon; Eskildsen, Simon Fristed; Fonov, Vladimir S.; Gauthier, Serge G.; Poirier, Judes; Rosa Neto, Pedro (2023) [Artigo de periódico]
      Associations between pathophysiological events and cognitive measures provide insights regarding brain networks affected during the clinical progression of Alzheimer’s disease (AD). In this study, we assessed patients’ ...

    • Neuropsychiatric symptoms and microglial activation in patients with Alzheimer disease 

      Aguzzoli, Cristiano Schaffer; Zimmer, Eduardo Rigon; Rohden, Francieli; Pascoal, Tharick Ali (2023) [Artigo de periódico]
      IMPORTANCE: Neuropsychiatric symptoms are commonly encountered and are highly debilitating in patients with Alzheimer disease. Understanding their underpinnings has implications for identifying biomarkers and treatment for ...

    • Race-related population attributable fraction of preventable risk factors of dementia : a latino population-based study 

      Borelli, Wyllians José Vendramini; Formoso, Carolina Rodrigues; Bieger, Andrei; Ferreira, Pâmela Cristina Lukasewicz; Zimmer, Eduardo Rigon; Pascoal, Tharick Ali; Chaves, Marcia Lorena Fagundes; Castilhos, Raphael Machado de (2023) [Artigo de periódico]
      Background: risk factors for dementia have distinct frequency and impact in relation to race. Our aim was to identify differences in modifiable risk factors of dementia related to races and estimate their population ...

    • Seleção de Características com kNN-SMOTE em atributos do Mal de Alzheimer 

      Rodrigues, Yuri Elias; Manica, Evandro; Zimmer, Eduardo Rigon; Rosa Neto, Pedro; Pascoal, Tharick Ali (2015) [Resumo publicado em evento]

    • Soluble amyloid-beta isoforms predict downstream Alzheimer’s disease pathology 

      Povala, Guilherme; Bellaver, Bruna; De Bastiani, Marco Antônio; Brum, Wagner Scheeren; Ferreira, Pâmela Cristina Lukasewicz; Bieger, Andrei; Pascoal, Tharick Ali; Benedet, Andréa L.; Souza, Diogo Onofre Gomes de; Araújo, Ricardo Matsumura de; Zatt, Bruno; Rosa Neto, Pedro; Zimmer, Eduardo Rigon (2021) [Artigo de periódico]
      Background: Changes in soluble amyloid-beta (Aβ) levels in cerebrospinal fluid (CSF) are detectable at early preclinical stages of Alzheimer’s disease (AD). However, whether Aβ levels can predict downstream AD pathological ...

    • Subjective cognitive decline in Brazil : prevalence and association with dementia modifiable risk factors in a population-based study 

      Borelli, Wyllians José Vendramini; Zimmer, Eduardo Rigon; Bieger, Andrei; Coelho, Bruna; Pascoal, Tharick Ali; Chaves, Marcia Lorena Fagundes; Amariglio, Rebecca England; Castilhos, Raphael Machado de (2022) [Artigo de periódico]
      Introduction: Subjective cognitive decline (SCD) may be an early symptom of Alzheimer’s disease. We aimed to estimate the prevalence of SCD in Brazil and its association with dementia modifiable risk factors. Methods: We ...

    • The association of age-related and off-target retention with longitudinal quantification of [18F]MK6240 tau PET in target regions 

      Tissot, Cecile; Bellaver, Bruna; Zimmer, Eduardo Rigon; Pascoal, Tharick Ali (2023) [Artigo de periódico]
      6-(fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F] MK6240) tau PET tracer quantifies the brain tau neurofibrillary tangle load in Alzheimer disease. The aims of our study were to test the stability ...

    • A three-range approach enhances the prognostic utility of CSF biomarkers in Alzheimer's disease 

      Brum, Wagner Scheeren; De Bastiani, Marco Antônio; Bieger, Andrei; Therriault, Joseph; Souza, João Pedro Ferrari; Benedet, Andréa L.; Saha-Chaudhuri, Paramita; Souza, Diogo Onofre Gomes de; Ashton, Nicholas J.; Zetterberg, Henrik; Pascoal, Tharick Ali; Karikari, Thomas K.; Blennow, Kaj; Rosa Neto, Pedro; Zimmer, Eduardo Rigon; Alzheimer’s Disease Neuroimaging Initiative (2022) [Artigo de periódico]
      Introduction: Alzheimer's disease consensus recommends biomarker dichotomization, a practice with well-described clinical strengths and methodological limitations. Although neuroimaging studies have explored alternative ...

    • Wrappers feature selection in alzheimer’s biomarkers using kNN and SMOTE oversampling 

      Rodrigues, Yuri Elias; Manica, Evandro; Zimmer, Eduardo Rigon; Pascoal, Tharick Ali; Mathotaarachchi, Sulantha Sanjeewa; Rosa Neto, Pedro (2017) [Artigo de periódico]
      Biomarkers are characteristics that are objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes or pharmacological responses to a therapeutic intervention. The combination ...