Navegação Ciências da Saúde por Autor "Wajner, Simone Magagnin"
Resultados 1-18 de 18
-
Carcinoma diferenciado de tireóide : avaliação inicial e acompanhamento
Golbert, Lenara; Wajner, Simone Magagnin; Rocha, Andreia Possatti da; Maia, Ana Luiza Silva; Gross, Jorge Luiz (2005) [Artigo de periódico]O câncer de tireóide é responsável por cerca de 1% dos novos casos de doença maligna diagnosticados. A maioria destes tumores são carcinomas papilares e foliculares, também denominados de carcinomas diferenciados de tireóide ... -
Clinical implications of altered thyroid status in male testicular function
Wajner, Simone Magagnin; Wagner, Márcia dos Santos; Maia, Ana Luiza Silva (2009) [Artigo de periódico]Os hormônios da tireoide estão envolvidos virtualmente no desenvolvimento e na manutenção de todos os tecidos. As gônadas masculinas foram, por décadas, consideradas insensíveis aos hormônios tireoidianos. No entanto, ... -
Colorectal cancer in young patients : a case report
Rebelatto, Taiane Francieli; Bento, Luiza Haendchen; Salla, Rafaela Fenalti; Ries, Lucas Pires Stocker; Almeida, Felipe Augusto Santiago de; Fior, Bárbara Rayanne; Marobin, Roberta; Restelatto, Luciane Maria Fabian; Wajner, Simone Magagnin (2016) [Artigo de periódico] -
Decreased expression of the thyroid hormone-inactivating enzyme type 3 deiodinase is associated with lower survival rates in breast cancer
Goemann, Iuri Martin; Marczyk, Vicente Rodrigues; Recamonde-Mendoza, Mariana; Wajner, Simone Magagnin; Graudenz, Márcia Silveira; Maia, Ana Luiza Silva (2020) [Artigo de periódico]Thyroid hormones (THs) are critical regulators of cellular processes, while changes in their levels impact all the hallmarks of cancer. Disturbed expression of type 3 deiodinase (DIO3), the main TH-inactivating enzyme, ... -
DIO2 (deiodinase, iodothyronine, type II)
Maia, Ana Luiza Silva; Wajner, Simone Magagnin; Leiria, Leonardo Barbosa (2011) [Artigo de periódico] -
Liraglutide activates type 2 deiodinase and enhances β3-adrenergic-induced thermogenesis in mouse adipose tissue
Oliveira, Fernanda Cerqueira Barroso de; Bauer, Eduarda Jacinto; Ribeiro, Carolina Martins; Pereira, Sidney Alcântara; Beserra, Bruna T. S.; Wajner, Simone Magagnin; Maia, Ana Luiza Silva; Neves, Francisco de Assis Rocha; Coelho, Michella S.; Amato, Angélica Amorim (2022) [Artigo de periódico]Aims: Liraglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist used as an anti-hyperglycemic agent in type 2 diabetes treatment and recently approved for obesity management. Weight loss is attributed ... -
Low inflammatory stimulus increases D2 activity and modulates thyroid hormone metabolism during myogenesis in vitro
Oliveira, Thamires Siqueira de; Shimabukuro, Marilia Kimie; Monteiro, Victoria Regina Siqueira; Andrade, Cherley Borba Vieira de; Boelen, Anita; Wajner, Simone Magagnin; Maia, Ana Luiza Silva; Ortiga-Carvalho, Tania; Bloise, Flavia Fonseca (2022) [Artigo de periódico]Thyroid hormone (TH) signaling controls muscle progenitor cells differentiation. However, inflammation can alter muscle TH signaling by modulating the expression of TH transporters (Slc16a2), receptors (Thra1), and deiodinase ... -
Modulation of deiodinase types 2 and 3 during skeletal muscle regeneration
Ogawa-Wong, Ashley N.; Carmody, Colleen; Le, Katherine; Marschner, Rafael Aguiar; Larsen, P. Reed; Zavacki, Ann Marie; Wajner, Simone Magagnin (2022) [Artigo de periódico]The muscle stem-cell niche comprises numerous cell types, which coordinate the regeneration process after injury. Thyroid hormones are one of the main factors that regulate genes linked to skeletal muscle. In this way, ... -
New insights toward the acute non-thyroidal illness syndrome
Wajner, Simone Magagnin; Maia, Ana Luiza Silva (2012) [Artigo de periódico]The non-thyroidal illness syndrome (NTIS) refers to changes in serum thyroid hormone levels observed in critically ill patients in the absence of hypothalamic–pituitary–thyroid primary dysfunction. Affected individuals ... -
Non-thyroidal illness syndrome predicts outcome in adult critically ill patients : a systematic review and meta-analysis
Vidart, Josi; Jaskulski, Paula da Rocha; Kunzler, Ana Laura Fischer; Marschner, Rafael Aguiar; Silva, André Ferreira de Azeredo da; Wajner, Simone Magagnin (2022) [Artigo de periódico]We performed a systematic review and meta-analysis to comprehensively determine the prevalence and the prognostic role of non-thyroidal illness syndrome (NTIS) in critically ill patients. We included studies that assessed ... -
Papel do Fator de Crescimento Endotelial Vascular nos Carcinomas de Tireóide
Capp, Clarissa; Zennig, Nadja; Wajner, Simone Magagnin; Maia, Ana Luiza Silva (2009) [Artigo de periódico]O crescimento tumoral está diretamente relacionado com a neovascularização, a qual decorre do desequilíbrio entre os fatores pró-angiogênicos e antiangiogênicos, secretados pelas células neoplásicas O fator de crescimento ... -
O papel dos hormônios tireoidianos na função testicular
Wajner, Simone Magagnin; Wagner, Márcia dos Santos; Fernandes, Natália Sônego; Maia, Ana Luiza Silva (2008) [Artigo de periódico]Os hormônios tireoidianos são essenciais para o crescimento, desenvolvimento e metabolismo. O pró-hormônio tiroxina (T4) é sintetizado e secretado pela glândula tireóide junto com uma pequena quantidade do hormônio ativo, ... -
Relationship among low T3 levels, type 3 deiodinase, oxidative stress, and mortality in sepsis and septic shock : defining patient outcomes
Vidart, Josi; Axelrud, Luiza Kvitko; Braun, André Cardoso; Marschner, Rafael Aguiar; Wajner, Simone Magagnin (2023) [Artigo de periódico]Low T3 syndrome occurs frequently in patients with sepsis. Type 3 deiodinase (DIO3) is present in immune cells, but there is no description of its presence in patients with sepsis. Here, we aimed to determine the prognostic ... -
Short-term exercise training improves cardiac function associated to a better antioxidant response and lower type 3 iodothyronine deiodinase activity after myocardial infarction
Marschner, Rafael Aguiar; Banda, Patrícia Da Silva; Wajner, Simone Magagnin; Markoski, Melissa Medeiros; Schaun, Maximiliano Isoppo; Lehnen, Alexandre Machado (2019) [Artigo de periódico]Aims: We assessed the effects of a short-term exercise training on cardiac function, oxidative stress markers, and type 3 iodothyronine deiodinase (D3) activity in cardiac tissue of spontaneously hypertensive rats (SHR) ... -
Sodium selenite supplementation does not fully restore oxidative stress-induced deiodinase dysfunction : implications for the nonthyroidal illness syndrome
Wajner, Simone Magagnin; Rohenkohl, Helena Cecin; Serrano, Túlio Macário Graccho; Maia, Ana Luiza Silva (2015) [Artigo de periódico]Nonthyroidal illness syndrome (NTIS) is marked by low T3 and high reverse T3 levels. The physio- pathology is poorly understood but involves oxidative stress-induced disruption of the iodothyronine deiodinases, which ... -
T3 as predictor of mortality in any cause non-critically ill patients a systematic review and meta-analysis
Biegelmeyer, Erika; Scanagata, Iury Fernandes; Alves, Laura da Silva; Reveilleau, Murilo; Schwengber, Fernando Pereira; Wajner, Simone Magagnin (2021) [Artigo de periódico]Background: Low T3 syndrome refers to a set of thyroid hormone metabolism alterations present in the disease state. A correlation between low T3 and poor clinical outcomes in the intensive care unit is more established. ... -
The rs225017 polymorphism in the 3'UTR of the human DIO2 gene is associated with increased insulin resistance
Leiria, Leonardo Barbosa; Dora, José Miguel Silva; Wajner, Simone Magagnin; Estivalet, Aline Albeche Farias; Crispim, Daisy; Maia, Ana Luiza Silva (2014) [Artigo de periódico]The Thr92Ala (rs225014) polymorphism in the type 2 deiodinase (DIO2) gene has been associated with insulin resistance (IR) and decreased enzyme activity in human tissues but kinetic studies failed to detect changes in the ... -
Uncovering actions of type 3 deiodinase in the metabolic dysfunction-associated fatty liver disease (MAFLD)
Marschner, Rafael Aguiar; Roginski, Ana Cristina; Ribeiro, Rafael Teixeira; Longo, Larisse; Álvares-da-Silva, Mário Reis; Wajner, Simone Magagnin (2023) [Artigo de periódico]Metabolic dysfunction-associated fatty liver disease (MAFLD) has gained worldwide attention as a public health problem. Nonetheless, lack of enough mechanistic knowledge restrains effective treatments. It is known that ...