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dc.contributor.authorHackenhaar, Fernanda Schäferpt_BR
dc.contributor.authorMartinez, Denispt_BR
dc.contributor.authorKlein, Cristinipt_BR
dc.contributor.authorMedeiros, Tássia Machadopt_BR
dc.contributor.authorAlabarse, Paulo Vinicius Gilpt_BR
dc.contributor.authorWainstein, Marco Vugmanpt_BR
dc.contributor.authorGonçalves, Sandro Cadavalpt_BR
dc.contributor.authorBenfato, Mara da Silveirapt_BR
dc.date.accessioned2019-12-20T04:03:21Zpt_BR
dc.date.issued2015pt_BR
dc.identifier.issn1214-0287pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/203593pt_BR
dc.description.abstractElevated ferritin levels may lead to oxidative stress, and are associated with coronary artery disease (CAD). Sleep disordered breathing (SDB) is frequently present in atherosclerosis patients, and causes endothelial dysfunction leading to atherosclerotic plaque progression. Hypoxic conditions, such as SDB, may upregulate ferritin. The aim of this study was to evaluate ferritin levels in CAD patients and to correlate ferritin levels with parameters related to CAD progression, including SDB. We studied 27 patients with CAD (defined as >30% coronary narrowing) and 29 controls. We found that ferritin was increased in CAD patients, and was positively correlated with the apnea–hypopnea index (AHI), age, Creactive protein (CRP), transferrin, hemoglobin, and testosterone levels, and was negatively correlated with O2 saturation. Nitrites and nitrates, an indirect measure of nitric oxide ( NO) concentration, were lower in CAD patients, and were negatively correlated with ferritin. The increase in ferritin may be related to oxidative stress, suggesting a possible pro-atherosclerotic role of increased ferritin in CAD patients with SDB.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofJournal of applied biomedicine. České Budějovice, Czech Republic. Vol. 13, n. 4 (Sep. 2015), p. 289–298pt_BR
dc.rightsOpen Accessen
dc.subjectApneia obstrutiva do sonopt_BR
dc.subjectAterosclerosept_BR
dc.subjectFerritinaspt_BR
dc.subjectÓxido nítricopt_BR
dc.subjectEstresse oxidativopt_BR
dc.titleSerum ferritin levels may have a pro-atherosclerotic role in coronary artery disease patients with sleep disordered breathingpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000997289pt_BR
dc.type.originEstrangeiropt_BR


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