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Umbilical cord blood and neonatal endothelin-1 levels in preterm newborns with and without respiratory distress syndrome
dc.contributor.author | Benjamin, Ana Claudia Weber | pt_BR |
dc.contributor.author | Silveira, Rita de Cássia dos Santos | pt_BR |
dc.contributor.author | Procianoy, Renato Soibelmann | pt_BR |
dc.date.accessioned | 2010-04-27T04:16:47Z | pt_BR |
dc.date.issued | 2005 | pt_BR |
dc.identifier.issn | 0100-879X | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/21277 | pt_BR |
dc.description.abstract | Increased pulmonary vascular resistance in preterm newborn infants with respiratory distress syndrome is suggested, and endothelin-1 plays an important role in pulmonary vascular reactivity in newborns. We determined umbilical cord blood and neonatal (second sample) levels of endothelin-1 in 18 preterm newborns with respiratory distress syndrome who had no clinical or echocardiographic diagnosis of pulmonary hypertension and 22 without respiratory distress syndrome (gestational ages: 31.4 ± 1.6 and 29.3 ± 2.3 weeks, respectively). Umbilical cord blood and a second blood sample taken 18 to 40 h after birth were used for endothelin-1 determination by enzyme immunoassay. Median umbilical cord blood endothelin-1 levels were similar in both groups (control: 10.9 and respiratory distress syndrome: 11.4 pg/mL) and were significantly higher than in the second sample (control: 1.7 pg/mL and respiratory distress syndrome: 3.5 pg/mL, P < 0.001 for both groups). Median endothelin-1 levels in the second sample were significantly higher in children with respiratory distress syndrome than in control infants (P < 0.001). There were significant positive correlations between second sample endothelin-1 and Score for Neonatal Acute Physiology and Perinatal Extension II (r = 0.36, P = 0.02), and duration of mechanical ventilation (r = 0.64, P = 0.02). A slower decline of endothelin-1 from birth to 40 h of life was observed in newborns with respiratory distress syndrome when compared to controls. A significant correlation between neonatal endothelin-1 levels and some illness-severity signs suggests that endothelin-1 plays a role in the natural course of respiratory distress syndrome in preterm newborns. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | por | pt_BR |
dc.relation.ispartof | Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 38, n. 9 (set. 2005), p. 1417-1422. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Endotelina-1 | pt_BR |
dc.subject | Prematuridade | pt_BR |
dc.subject | Hipertensão pulmonar | pt_BR |
dc.subject | Síndrome do desconforto respiratório do recém-nascido | pt_BR |
dc.title | Umbilical cord blood and neonatal endothelin-1 levels in preterm newborns with and without respiratory distress syndrome | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000508388 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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