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dc.contributor.authorVieira, Jaqueline Leitept_BR
dc.contributor.authorMaurmann, Natashapt_BR
dc.contributor.authorVenturini Junior, Janiopt_BR
dc.contributor.authorPranke, Patricia Helena Lucaspt_BR
dc.contributor.authorBergmann, Carlos Perezpt_BR
dc.date.accessioned2020-12-17T04:10:14Zpt_BR
dc.date.issued2020pt_BR
dc.identifier.issn2372-0964pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/216643pt_BR
dc.description.abstractCurrently, magnetic nanoparticles are widely studied with regard to their application in cancer treatment. This study aims to show a straightforward strategy for the production of Fe3O4 nanoparticles (NPs) with biocompatible surface modifications with polycaprolactone (PCL) for biomedical purposes. The effects of the polymer coating on the properties of magnetite were evaluated. Crystallinity, morphology, composition, hydrodynamic size and magnetic properties of the produced nanoparticles were analysed via X-ray diffractometry (XRD), Transmission Electron Microscopy (TEM), Fourier-Transform Infrared Spectroscopy (FTIR), Dynamic Light Scattering (DLS) and Vibrating Sample Magnetometry (VSM), respectively. The proposed method produced nanoparticles of magnetite with an average size between 9 and 11 nm, with spherical morphology and superparamagnetic properties. Magnetization values were not compromised even when the highest amount of polymer was used in the surface modification. On the other hand, the coating resulted in the decrease of the hydrodynamic size of the composites, indicating greater colloidal stability when the polymer was present. The obtained nanoparticles showed maintenance of significant superparamagneticbehavior, even in the presence of PCL on their surface. This phenomenon would allow for their application as a further optimized vector in hyperthermia cancer treatment, controlled drug delivery and resonance imaging.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofSOJ Materials Science & Engineering [recurso eletrônico]. Normal-Illinois, USA: Symbiosis. Vol. 7, no. 1 (2020), 6 p.pt_BR
dc.rightsOpen Accessen
dc.subjectNanopartículaspt_BR
dc.subjectNanoparticlesen
dc.subjectMagnetiteen
dc.subjectMagnetitapt_BR
dc.subjectPCLen
dc.subjectNeoplasiaspt_BR
dc.subjectCanceren
dc.subjectFebrept_BR
dc.subjectHyperthermiaen
dc.titleProduction and characterization of magnetic Fe3O4 nanoparticles coated with PCL for biomedical applicationspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001119342pt_BR
dc.type.originEstrangeiropt_BR


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