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dc.contributor.authorTirloni, Lucaspt_BR
dc.contributor.authorReck, Josépt_BR
dc.contributor.authorTerra, Renata Maria Soarespt_BR
dc.contributor.authorMartins, Joao Ricardopt_BR
dc.contributor.authorMulenga, Albertpt_BR
dc.contributor.authorSherman, Nicholas E.pt_BR
dc.contributor.authorFox, Jay Williampt_BR
dc.contributor.authorYates, Jonh R.pt_BR
dc.contributor.authorTermignoni, Carlospt_BR
dc.contributor.authorPinto, Antonio Frederico Michelpt_BR
dc.contributor.authorVaz Junior, Itabajara da Silvapt_BR
dc.date.accessioned2021-08-13T04:37:12Zpt_BR
dc.date.issued2014pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/225609pt_BR
dc.description.abstractThe cattle tick Rhipicephalus (Boophilus) microplus is one of the most harmful parasites affecting bovines. Similarly to other hematophagous ectoparasites, R. microplus saliva contains a collection of bioactive compounds that inhibit host defenses against tick feeding activity. Thus, the study of tick salivary components offers opportunities for the development of immunological based tick control methods and medicinal applications. So far, only a few proteins have been identified in cattle tick saliva. The aim of this work was to identify proteins present in R. microplus female tick saliva at different feeding stages. Proteomic analysis of R. microplus saliva allowed identifying peptides corresponding to 187 and 68 tick and bovine proteins, respectively. Our data confirm that (i) R. microplus saliva is complex, and (ii) that there are remarkable differences in saliva composition between partially engorged and fully engorged female ticks. R. microplus saliva is rich mainly in (i) hemelipoproteins and other transporter proteins, (ii) secreted cross-tick species conserved proteins, (iii) lipocalins, (iv) peptidase inhibitors, (v) antimicrobial peptides, (vii) glycine-rich proteins, (viii) housekeeping proteins and (ix) host proteins. This investigation represents the first proteomic study about R. microplus saliva, and reports the most comprehensive Ixodidae tick saliva proteome published to date. Our results improve the understanding of tick salivary modulators of host defense to tick feeding, and provide novel information on the tick-host relationship.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofPlos One. San Francisco. Vol. 9, no. 4 (Apr. 2014), e94831, 19 p.pt_BR
dc.rightsOpen Accessen
dc.subjectBiotecnologia : Animalpt_BR
dc.subjectRhipicephalus micropluspt_BR
dc.subjectCarrapatos : Bovinospt_BR
dc.titleProteomic analysis of cattle tick rhipicephalus (Boophilus) microplus saliva: a comparison between partially and fully engorged femalespt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000917123pt_BR
dc.type.originEstrangeiropt_BR


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