Coxiella endosymbiont of Rhipicephalus microplus modulates tick physiology with a major impact in blood feeding capacity
dc.contributor.author | Guizzo, Melina Garcia | pt_BR |
dc.contributor.author | Tirloni, Lucas | pt_BR |
dc.contributor.author | Gonzalez, Sergio Alberto | pt_BR |
dc.contributor.author | Farber, Marisa Diana | pt_BR |
dc.contributor.author | Braz, Glória Regina Cardoso | pt_BR |
dc.contributor.author | Parizi, Luis Fernando | pt_BR |
dc.contributor.author | Silva, Lucas André Dedavid e | pt_BR |
dc.contributor.author | Vaz Junior, Itabajara da Silva | pt_BR |
dc.contributor.author | Oliveira, Pedro Lagerblad de | pt_BR |
dc.date.accessioned | 2022-06-25T05:08:20Z | pt_BR |
dc.date.issued | 2022 | pt_BR |
dc.identifier.issn | 1664-302x | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/241212 | pt_BR |
dc.description.abstract | In the past decade, metagenomics studies exploring tick microbiota have revealed widespread interactions between bacteria and arthropods, including symbiotic interactions. Functional studies showed that obligate endosymbionts contribute to tick biology, affecting reproductive fitness and molting. Understanding the molecular basis of the interaction between ticks and their mutualist endosymbionts may help to develop control methods based on microbiome manipulation. Previously, we showed that Rhipicephalus microplus larvae with reduced levels of Coxiella endosymbiont of R. microplus (CERM) were arrested at the metanymph life stage (partially engorged nymph) and did not molt into adults. In this study, we performed a transcriptomic differential analysis of the R. microplus metanymph in the presence and absence of its mutualist endosymbiont. The lack of CERM resulted in an altered expression profile of transcripts from several functional categories. Gene products such as DA-P36, protease inhibitors, metalloproteases, and evasins, which are involved in blood feeding capacity, were underexpressed in CERM-free metanymphs. Disregulation in genes related to extracellular matrix remodeling was also observed in the absence of the symbiont. Taken together, the observed alterations in gene expression may explain the blockage of development at the metanymph stage and reveal a novel physiological aspect of the symbiont-tick-vertebrate host interaction. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Frontiers in Microbiology. Lausanne. Vol. 13 (May 2022), 868575, 13 p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Symbiont | en |
dc.subject | Simbiose | pt_BR |
dc.subject | Microbiome | en |
dc.subject | Coxiella | pt_BR |
dc.subject | Tick | en |
dc.subject | Rhipicephalus microplus | pt_BR |
dc.subject | Transcriptome | en |
dc.subject | Alimentação hematófaga | pt_BR |
dc.subject | Crescimento e desenvolvimento | pt_BR |
dc.subject | Transcriptoma | pt_BR |
dc.title | Coxiella endosymbiont of Rhipicephalus microplus modulates tick physiology with a major impact in blood feeding capacity | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001140670 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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