Set-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage forms
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Abstract
A reliable method using LC-UV to assay mometasone furoate (MF) in creams or nasal sprays using the same chromatographic conditions was set up. Methanol:water 80:20 (v/v) (1.0 mL min-1) was used as mobile phase. MF was detected at 248 nm and analyzed in a concentration range from 1.0 to 20.0 μg mL-1. The method provided acceptable theoretical plates, peak simmetry, peak tailing factor and peak resolution a short run (5 min). The method showed specificity, good linearity (r = 0.9999) and the quan ...
A reliable method using LC-UV to assay mometasone furoate (MF) in creams or nasal sprays using the same chromatographic conditions was set up. Methanol:water 80:20 (v/v) (1.0 mL min-1) was used as mobile phase. MF was detected at 248 nm and analyzed in a concentration range from 1.0 to 20.0 μg mL-1. The method provided acceptable theoretical plates, peak simmetry, peak tailing factor and peak resolution a short run (5 min). The method showed specificity, good linearity (r = 0.9999) and the quantification limit was 0.379 μg mL-1. Furthermore, the method was precise (RSD < 2.0%), accurate (recovery > 97%) and robust. ...
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Química nova. São Paulo. Vol. 35, n. 4, (2012), p. 818-821
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Artigos de Periódicos (39124)Ciências da Saúde (10550)
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Artigos de Periódicos (39124)Ciências Exatas e da Terra (5955)
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