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dc.contributor.authorLourenço, Eloir D.pt_BR
dc.contributor.authorAmaral, Viviane Souza dopt_BR
dc.contributor.authorLehmann, Mauríciopt_BR
dc.contributor.authorDihl, Rafael Rodriguespt_BR
dc.contributor.authorSchmitt, Virginia M.pt_BR
dc.contributor.authorCunha, Kenya Silvapt_BR
dc.contributor.authorReguly, Maria Luizapt_BR
dc.contributor.authorAndrade, Heloisa Helena Rodrigues dept_BR
dc.date.accessioned2013-11-21T01:48:11Zpt_BR
dc.date.issued2010pt_BR
dc.identifier.issn1415-4757pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/81189pt_BR
dc.description.abstractThis study evaluated the clastogenic and/or aneugenic potential of three nucleoside reverse transcriptase inhibitors (zidovudine - AZT, lamivudine - 3TC and stavudine - d4T) using the cytokinesis-block micronucleus (CBMN) assay in human lymphocyte cultures. All three inhibitors produced a positive response when tested in binucleated cells. The genotoxicity of AZT and 3TC was restricted to binucleated cells since there was no significant increase in the frequency of micronuclei in mononucleated cells. This finding indicated that AZT and 3TC caused chromosomal breakage and that their genotoxicity was related to a clastogenic action. In addition to the positive response observed with d4T in binucleated cells, this drug also increased the frequency of micronuclei in mononucleated cells, indicating clastogenic and aneugenic actions. Since the structural differences between AZT and 3TC and AZT and d4T involve the 3’ position in the 2’-deoxyribonucleoside and in an unsaturated 2’,3’,dideoxyribose, respectively, we suggest that an unsaturated 2’, 3’, dideoxyribose is responsible for the clastogenic and aneugenic actions of d4T.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofGenetics and molecular biology. Vol. 33, n. 4 (out./dez. 2010), p. 756-760pt_BR
dc.rightsOpen Accessen
dc.subjectLamivudinapt_BR
dc.subjectLamivudineen
dc.subjectTestes para micronúcleospt_BR
dc.subjectMicronucleus assayen
dc.subjectStavudineen
dc.subjectEstavudinapt_BR
dc.subjectZidovudinapt_BR
dc.subjectTranscriptase inhibitorsen
dc.subjectZidovudineen
dc.titleMicronuclei induced by reverse transcriptase inhibitors in mononucleated and binucleated cells as assessed by the cytokinesis-block micronucleus assaypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000778519pt_BR
dc.type.originNacionalpt_BR


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