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dc.contributor.authorBonato, Cassiane Cardosopt_BR
dc.contributor.authorDias, Henrique Bregolinpt_BR
dc.contributor.authorAlves, Michele da Silvapt_BR
dc.contributor.authorDuarte, Lucas Ostpt_BR
dc.contributor.authorDias, Telpo Martinspt_BR
dc.contributor.authorDalenogare, Maiara Oliveirapt_BR
dc.contributor.authorViegas, C.C.B.pt_BR
dc.contributor.authorElnecave, Regina Helenapt_BR
dc.date.accessioned2014-11-26T02:30:28Zpt_BR
dc.date.issued2014pt_BR
dc.identifier.issn1460-3969pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/107476pt_BR
dc.description.abstractBackground: During radiation therapy, unwanted scatter to healthy tissues outside the target field may occur. Children and adolescents are more sensitive to radiation injury, and the thyroid gland is particularly susceptible to these effects. Purpose: To assess acute changes in thyroid function and volume in children and adolescents undergoing radiotherapy for a variety of non-thyroid cancers. Materials and Methods: Thirty-one children and adolescents underwent radiation therapy of various body areas in which the thyroid was not included. Thyroid-stimulating hormone (TSH), thyroxine (T4), free thyroxine (fT4), triiodothyronine (T3), anti-thyroperoxidase antibodies and thyroglobulin were measured before, on the last day and at 1 and 3 months after the end of radiotherapy. Ultrasound scans were taken and 6- and 24-hour¹³¹I uptake was measured before and after treatment. The scattered dose to the thyroid region was estimated with a treatment planning system or measured with thermoluminescent dosimeters. Results: The median radiation dose scattered to the thyroid was 296∙6 cGy (IQR 16∙7–1,709∙0). Levels of TSH (p=0∙575), T4 (p=0∙950), fT4 (p=0∙510), T3 (p=0∙842), thyroglobulin (p=0∙620) and anti-thyroid peroxidase antibodies (p=0∙546) were statistically similar at all four time points. There were no differences between pre- and post-radiotherapy thyroid volume and ¹³¹I uptake (p=0∙692 and 0∙92, respectively). Conclusion: More sensitive methods may be required to ascertain whether acute injury to the follicular epithelium occurs with lower radiation doses scattered to the thyroid.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofJournal of radiotherapy in practice. United Kingdom. Vol. 13, no. 3 (Sept. 2014), p. 310-316.pt_BR
dc.rightsOpen Accessen
dc.subjectAdolescentept_BR
dc.subjectAcute effectsen
dc.subjectCriançapt_BR
dc.subjectAdolescenten
dc.subjectChilden
dc.subjectRadioterapiapt_BR
dc.subjectGlândula tireóidept_BR
dc.subjectRadiotherapyen
dc.subjectThyroid glanden
dc.titleAcute effects on the thyroid gland after non-directed radiation therapy in children and adolescentspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000945457pt_BR
dc.type.originEstrangeiropt_BR


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