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dc.contributor.authorAlmeida, Juliana S.pt_BR
dc.contributor.authorLima, Fernandapt_BR
dc.contributor.authorRos, Simoní dapt_BR
dc.contributor.authorBulhões, Luis O.S.pt_BR
dc.contributor.authorCarvalho, Leandro Machado dept_BR
dc.contributor.authorBeck, Ruy Carlos Ruverpt_BR
dc.date.accessioned2015-02-11T02:18:08Zpt_BR
dc.date.issued2010pt_BR
dc.identifier.issn1556-276xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/109964pt_BR
dc.description.abstractThe improvement of the rutin photostability and its prolonged in vitro antioxidant activity were studied by means of its association with nanostructured aqueous dispersions. Rutin-loaded nanocapsules and rutin-loaded nanoemulsion showed mean particle size of 124.30 ± 2.06 and 124.17 ± 1.79, respectively, polydispersity index below 0.20, negative zeta potential, and encapsulation efficiency close to 100%. The in vitro antioxidant activity was evaluated by the formation of free radical OH after the exposure of hydrogen peroxide to a UV irradiation system. Rutin-loaded nanostructures showed lower rutin decay rates [(6.1 ± 0.6) 10-3 and (5.1 ± 0.4) 10-3 for nanocapsules and nanoemulsion, respectively] compared to the ethanolic solution [(35.0 ± 3.7) 10-3 min-1] and exposed solution [(40.1 ± 1.7) 10-3 min-1] as well as compared to exposed nanostructured dispersions [(19.5 ± 0.5) 10-3 and (26.6 ± 2.6) 10-3, for nanocapsules and nanoemulsion, respectively]. The presence of the polymeric layer in nanocapsules was fundamental to obtain a prolonged antioxidant activity, even if the mathematical modeling of the in vitro release profiles showed high adsorption of rutin to the particle/droplet surface for both formulations. Rutinloaded nanostructures represent alternatives to the development of innovative nanomedicines.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofNanoscale research letters. New York. Vol. 5, n. 10 (July 2010), p. 1603-1610pt_BR
dc.rightsOpen Accessen
dc.subjectAntioxidant activityen
dc.subjectNanocápsulaspt_BR
dc.subjectNanocapsulesen
dc.subjectAtividade antioxidantept_BR
dc.subjectNanoemulsionsen
dc.subjectRutinapt_BR
dc.subjectNanoparticlesen
dc.subjectPhotostabilityen
dc.subjectRutinen
dc.titleNanostructured systems containing rutin: in vitro antioxidant activity and photostability studiespt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000777855pt_BR
dc.type.originEstrangeiropt_BR


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